Aaron J DeBono
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Explore the profile of Aaron J DeBono including associated specialties, affiliations and a list of published articles.
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7
Citations
59
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Recent Articles
1.
Deora G, Qin C, Vecchio E, DeBono A, Priebbenow D, Brady R, et al.
J Med Chem
. 2019 May;
62(10):5242-5248.
PMID: 31038950
Herein we describe the development of a focused series of functionalized pyridazin-3(2 H)-one-based formyl peptide receptor (FPR) agonists that demonstrate high potency and biased agonism. The compounds described demonstrated biased...
2.
Muthiah D, Henshaw G, DeBono A, Capuano B, Scammells P, Callaghan R
Drug Metab Dispos
. 2018 Nov;
47(2):164-172.
PMID: 30478158
The antitussive agent noscapine has been shown to inhibit the proliferation of cancer cells by disruption of tubulin dynamic. However, the efficacy of several anticancer drugs that inhibit tublin dynamics...
3.
Qin C, May L, Sexton P, DeBono A, Baell J, Christopoulos A, et al.
Nat Commun
. 2018 Feb;
9(1):530.
PMID: 29416022
No abstract available.
4.
Dennis M, Lee M, Harjani J, Ahmed M, DeBono A, Pitcher N, et al.
Chemistry
. 2017 Nov;
24(8):1922-1930.
PMID: 29171692
Dihydropteroate synthase (DHPS) is an enzyme of the folate biosynthesis pathway, which catalyzes the formation of 7,8-dihydropteroate (DHPt) from 6-hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPPP) and para-aminobenzoic acid (pABA). DHPS is the long-standing...
5.
Dennis M, Pitcher N, Lee M, DeBono A, Wang Z, Harjani J, et al.
J Med Chem
. 2016 Apr;
59(11):5248-63.
PMID: 27094768
6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is a member of the folate biosynthesis pathway found in prokaryotes and lower eukaryotes that catalyzes the pyrophosphoryl transfer from the ATP cofactor to a 6-hydroxymethyl-7,8-dihydropterin substrate....
6.
DeBono A, Mistry S, Xie J, Muthiah D, Phillips J, Ventura S, et al.
ChemMedChem
. 2013 Dec;
9(2):399-410.
PMID: 24339417
Noscapine, a phthalideisoquinoline alkaloid derived from Papaver somniferum, is a well-known antitussive drug that has a relatively safe in vitro toxicity profile. Noscapine is also known to possess weak anticancer...
7.
DeBono A, Xie J, Ventura S, Pouton C, Capuano B, Scammells P
ChemMedChem
. 2012 Oct;
7(12):2122-33.
PMID: 23055449
Noscapine is a phthalideisoquinoline alkaloid isolated from the opium poppy Papaver somniferum. It has long been used as an antitussive agent, but has more recently been found to possess microtubule-modulating...