Dirk Wohlleber
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Explore the profile of Dirk Wohlleber including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
1763
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Recent Articles
21.
OConnor T, Zhou X, Kosla J, Adili A, Beccaria M, Kotsiliti E, et al.
Cancer Cell
. 2019 Sep;
36(3):250-267.e9.
PMID: 31526758
How lymphoma cells (LCs) invade the brain during the development of central nervous system lymphoma (CNSL) is unclear. We found that NF-κB-induced gliosis promotes CNSL in immunocompetent mice. Gliosis elevated...
22.
Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim H, Roelli P, et al.
Nature
. 2019 Jun;
571(7764):265-269.
PMID: 31207605
Cytotoxic T cells are essential mediators of protective immunity to viral infection and malignant tumours and are a key target of immunotherapy approaches. However, prolonged exposure to cognate antigens often...
23.
Schneider A, Kurz S, Manske K, Janas M, Heikenwalder M, Misgeld T, et al.
Sci Rep
. 2019 Jun;
9(1):8492.
PMID: 31186476
Mitochondria are key for cellular metabolism and signalling processes during viral infection. We report a methodology to analyse mitochondrial properties at the single-organelle level during viral infection using a recombinant...
24.
Manske K, Kallin N, Konig V, Schneider A, Kurz S, Bosch M, et al.
Hepatology
. 2018 May;
68(6):2089-2105.
PMID: 29729204
The liver bears unique immune properties that support both immune tolerance and immunity, but the mechanisms responsible for clearance versus persistence of virus-infected hepatocytes remain unclear. Here, we dissect the...
25.
Holland T, Wohlleber D, Marx S, Kreutzberg T, Vento-Asturias S, Schmitt-Mbamunyo C, et al.
J Allergy Clin Immunol
. 2017 Aug;
141(1):416-419.e10.
PMID: 28826775
No abstract available.
26.
Coch C, Stumpel J, Lilien-Waldau V, Wohlleber D, Kummerer B, Bekeredjian-Ding I, et al.
Mol Ther
. 2017 Aug;
25(9):2093-2103.
PMID: 28760668
Influenza A virus infection causes substantial morbidity and mortality in seasonal epidemic outbreaks, and more efficient treatments are urgently needed. Innate immune sensing of viral nucleic acids stimulates antiviral immunity,...
27.
Schrom E, Huber M, Aneja M, Dohmen C, Emrich D, Geiger J, et al.
Mol Ther Nucleic Acids
. 2017 Jun;
7:350-365.
PMID: 28624211
Changes in lifestyle and environmental conditions give rise to an increasing prevalence of liver and lung fibrosis, and both have a poor prognosis. Promising results have been reported for recombinant...
28.
Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, et al.
Cancer Cell
. 2017 Jun;
31(6):771-789.e6.
PMID: 28609656
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant, heterogeneous cancer with poor treatment options. We found that mitochondrial dysfunction and oxidative stress trigger a niche favoring cholangiocellular overgrowth and tumorigenesis. Liver...
29.
Volckmar J, Gereke M, Ebensen T, Riese P, Philipsen L, Lienenklaus S, et al.
Sci Rep
. 2017 Mar;
7:43985.
PMID: 28266658
Hepatotropic viruses such as hepatitis C virus cause life-threatening chronic liver infections in millions of people worldwide. Targeted in vivo antigen-delivery to cross-presenting dendritic cells (DCs) has proven to be...
30.
Wohlleber D, Knolle P
Clin Transl Immunology
. 2017 Jan;
5(12):e117.
PMID: 28090319
Although the liver's function as unique immune organ regulating immunity has received a lot of attention over the last years, the mechanisms determining hepatic immune surveillance against infected hepatocytes remain...