Dirk Hoffmann
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Explore the profile of Dirk Hoffmann including associated specialties, affiliations and a list of published articles.
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40
Citations
592
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Recent Articles
1.
Heuer S, Burghaus I, Gose M, Kessler T, Sahm F, Vollmuth P, et al.
BMC Cancer
. 2024 Jan;
24(1):135.
PMID: 38279087
Background: Glioblastoma is the most frequent and a particularly malignant primary brain tumor with no efficacy-proven standard therapy for recurrence. It has recently been discovered that excitatory synapses of the...
2.
Ciprut S, Berberich A, Knoll M, Pusch S, Hoffmann D, Furkel J, et al.
Neurooncol Adv
. 2022 Aug;
4(1):vdac098.
PMID: 35919070
Background: Targeted immunotherapies are of growing interest in the treatment of various cancers. B7 homolog 3 protein (B7-H3), a member of the co-stimulatory/-inhibitory B7-family, exerts immunosuppressive and pro-tumorigenic functions in...
3.
Baron Y, Sens J, Lange L, Nassauer L, Klatt D, Hoffmann D, et al.
Mol Ther Nucleic Acids
. 2022 Feb;
27:810-823.
PMID: 35141043
DNA-modifying technologies, such as the CRISPR-Cas9 system, are promising tools in the field of gene and cell therapies. However, high and prolonged expression of DNA-modifying enzymes may cause cytotoxic and...
4.
Sehasseh E, Fernandez P, Kuhn S, Stiner M, Mentzer S, Colarossi D, et al.
Sci Adv
. 2021 Sep;
7(39):eabi8620.
PMID: 34550742
Ornaments such as beads are among the earliest signs of symbolic behavior among human ancestors. Their appearance signals important developments in both cognition and social relations. This paper describes and...
5.
Hassan J, Lieske A, Dorpmund N, Klatt D, Hoffmann D, Kleppa M, et al.
Int J Mol Sci
. 2021 Sep;
22(17).
PMID: 34502319
and are frequently upregulated in acute myeloid leukemia (AML), including those with MLL-rearrangement. Because of their pivotal role in hemostasis, HOXA9 and MEIS1 appear non-druggable. We, thus, interrogated gene expression...
6.
Hoffmann D, Sens J, Brennig S, Brand D, Philipp F, Vollmer Barbosa P, et al.
J Pers Med
. 2021 Apr;
11(3).
PMID: 33804706
Patient material from rare diseases such as very early-onset inflammatory bowel disease (VEO-IBD) is often limited. The use of patient-derived induced pluripotent stem cells (iPSCs) for disease modeling is a...
7.
Sens J, Hoffmann D, Lange L, Vollmer Barbosa P, Morgan M, Falk C, et al.
Hum Gene Ther
. 2020 Oct;
32(1-2):77-95.
PMID: 33023317
Samples from patients with rare diseases, such as primary immunodeficiencies, are often limited, which hampers careful analysis of the pathomechanisms involved in immune cell dysregulation. To overcome this issue, induced...
8.
Ritter M, Klimiankou M, Klimenkova O, Schambach A, Hoffmann D, Schmidt A, et al.
Ann Hematol
. 2020 Aug;
99(10):2329-2338.
PMID: 32821971
Patients with the pre-leukemia bone marrow failure syndrome called severe congenital neutropenia (CN) have an approximately 15% risk of developing acute myeloid leukemia (AML; called here CN/AML). Most CN/AML patients...
9.
Lange L, Hoffmann D, Schwarzer A, Ha T, Philipp F, Lenz D, et al.
Stem Cell Reports
. 2020 Jul;
15(1):274.
PMID: 32668220
No abstract available.
10.
Hoffmann D, Kuehle J, Lenz D, Philipp F, Zychlinski D, Lachmann N, et al.
Gene Ther
. 2020 Feb;
27(6):297-306.
PMID: 32051561
Induced pluripotent stem cells (iPSCs) from patients with genetic disorders are a valuable source for in vitro disease models, which enable drug testing and validation of gene and cell therapies....