Dionisia P Sideris
Overview
Explore the profile of Dionisia P Sideris including associated specialties, affiliations and a list of published articles.
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17
Citations
2148
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Recent Articles
1.
Webb M, Sideris D
Int J Mol Sci
. 2020 Oct;
21(20).
PMID: 33066461
Mitochondrial dysfunction is associated with ageing, but the detailed causal relationship between the two is still unclear. We review the major phenomenological manifestations of mitochondrial age-related dysfunction including biochemical, regulatory...
2.
Sarraf S, Sideris D, Giagtzoglou N, Ni L, Kankel M, Sen A, et al.
Cell Rep
. 2019 Oct;
29(1):225-235.e5.
PMID: 31577952
PINK1 and Parkin are established mediators of mitophagy, the selective removal of damaged mitochondria by autophagy. PINK1 and Parkin have been proposed to act as tumor suppressors, as loss-of-function mutations...
3.
Webb M, Sideris D, Biddle M
Bioorg Med Chem Lett
. 2019 Apr;
29(11):1270-1277.
PMID: 30954429
Mitochondrial dysfunction is a causative and/or exacerbating feature of many pathologies. We discuss below approaches to modulate mitochondrial dysfunction that involve (1) increasing their energetic efficiency by targeting gene expression...
4.
Sekine S, Wang C, Sideris D, Bunker E, Zhang Z, Youle R
Mol Cell
. 2019 Feb;
73(5):1028-1043.e5.
PMID: 30733118
Mutations in PTEN-induced kinase 1 (PINK1) can cause recessive early-onset Parkinson's disease (PD). Import arrest results in PINK1 kinase activation specifically on damaged mitochondria, triggering Parkin-mediated mitophagy. Here, we show...
5.
Lazarou M, Sliter D, Kane L, Sarraf S, Wang C, Burman J, et al.
Nature
. 2015 Aug;
524(7565):309-314.
PMID: 26266977
Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates ubiquitin to activate the ubiquitin ligase parkin, which...
6.
Pickrell A, Huang C, Kennedy S, Ordureau A, Sideris D, Hoekstra J, et al.
Neuron
. 2015 Jul;
87(2):371-81.
PMID: 26182419
Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. PARK2 mutations cause early-onset forms of PD. PARK2 encodes an E3 ubiquitin...
7.
Chatzi A, Sideris D, Katrakili N, Pozidis C, Tokatlidis K
FEBS J
. 2013 Aug;
280(20):4960-9.
PMID: 23937629
The discovery of the mitochondrial intermembrane space assembly (MIA) pathway was followed by studies that focused mainly on the typical small substrates of this disulfide relay system and the interactions...
8.
Fogel A, Dlouhy B, Wang C, Ryu S, Neutzner A, Hasson S, et al.
Mol Cell Biol
. 2013 Jul;
33(18):3675-88.
PMID: 23878393
During autophagy, a double membrane envelops cellular material for trafficking to the lysosome. Human beclin-1 and its yeast homologue, Atg6/Vps30, are scaffold proteins bound in a lipid kinase complex with...
9.
Kim S, Sideris D, Sevier C, Kaiser C
J Cell Biol
. 2012 Mar;
196(6):713-25.
PMID: 22412017
The endoplasmic reticulum (ER) provides an environment optimized for oxidative protein folding through the action of Ero1p, which generates disulfide bonds, and Pdi1p, which receives disulfide bonds from Ero1p and...
10.
Sideris D, Tokatlidis K
Methods Mol Biol
. 2010 Apr;
619:411-23.
PMID: 20419425
The MIA40 pathway is a novel import pathway in mitochondria specific for cysteine-rich proteins of the intermembrane space (IMS). The newly synthesised precursors are trapped in the IMS by a...