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» Authors » Dimitris Kardassis

Dimitris Kardassis

Explore the profile of Dimitris Kardassis including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 90
Citations 1226
Followers 0
Related Specialties
Biochemistry
Cell Biology
Endocrinology
Top 10 Co-Authors
Vassilis I Zannis
Angeliki Chroni
Efstathia Thymiakou
Panagiotis Fotakis
Maya Simionescu
Aristidis Moustakas
Christos Stournaras
Paraskevi Papakosta
Eleftheria Vasilaki
Ioanna Tiniakou
Published In
J Biol Chem
Biochemistry
Metabolism
J Lipid Res
Biochem Biophys Res Commun
Affiliations
Soon will be listed here.
Recent Articles
1.
Dantrolene is an HDL-associated paraoxonase-1 activator with immunosuppressive and atheroprotective properties
Dedemadi A, Sevdali E, Georgiadou D, Valanti E, Neofotistou-Themeli E, Chanis T, et al.
Biochim Biophys Acta Mol Cell Biol Lipids . 2025 Jan; 1870(2):159596. PMID: 39842506
Human paraoxonase 1 (PON1), an enzyme bound to high-density lipoprotein (HDL), hydrolyzes oxidized lipids and contributes to HDL atheroprotective functions. Decreased serum paraoxonase and arylesterase activities of PON1 have been...
2.
Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges
Sopic M, Karaduzovic-Hadziabdic K, Kardassis D, Maegdefessel L, Martelli F, Meerson A, et al.
J Mol Cell Cardiol Plus . 2025 Jan; 6():100048. PMID: 39802625
Atherosclerotic disease is a major cause of acute cardiovascular events. A deeper understanding of its underlying mechanisms will allow advancing personalized and patient-centered healthcare. Transcriptomic research has proven to be...
3.
Unravelling molecular mechanisms in atherosclerosis using cellular models and omics technologies
Kardassis D, Vindis C, Stancu C, Toma L, Gafencu A, Georgescu A, et al.
Vascul Pharmacol . 2024 Dec; 158:107452. PMID: 39667548
Despite the discovery and prevalent clinical use of potent lipid-lowering therapies, including statins and PCSK9 inhibitors, cardiovascular diseases (CVD) caused by atherosclerosis remain a large unmet clinical need, accounting for...
4.
Cytokeratin 18 as a Novel Biomarker in Patients with Hypertrophic Cardiomyopathy
Fragkiadakis K, Ktena N, Kalantidou A, Dermitzaki E, Anastasiou I, Papathanassiou S, et al.
Cells . 2024 Aug; 13(16. PMID: 39195218
Hypertrophic cardiomyopathy (HCM) is a heart muscle disease associated with an increased risk for sudden cardiac death (SCD). Cytokeratin 18-based proteins, such as M30 and M65 antigens, are known cell-death...
5.
Safety, Tolerability, and Pharmacodynamics of AZD3366 (Optimized Human CD39L3 Apyrase) Alone and in Combination With Ticagrelor and Acetylsalicylic Acid: A Phase 1, Randomized, Placebo-Controlled Study
Kardassis D, Egnell A, Astrand M, Daniels S, Whatling C, Fjellstrom O, et al.
J Am Heart Assoc . 2024 May; 13(11):e033985. PMID: 38804212
Background: ADP and ATP are importantly involved in vascular and thrombotic homeostasis, via multiple receptor pathways. Blockade of ADP P2Y receptors inhibits platelet aggregation and represents an effective cardiovascular disease...
6.
The science behind soft skills: Do's and Don'ts for early career researchers and beyond. A review paper from the EU-CardioRNA COST Action CA17129
Acharya S, Preda M, Papatheodorou I, Palioura D, Giardoglou P, Tsata V, et al.
Open Res Eur . 2024 May; 3:55. PMID: 38689633
Soft skills are the elementary management, personal, and interpersonal abilities that are vital for an individual to be efficient at workplace or in their personal life. Each work place requires...
7.
Impaired hepatic glucose metabolism and liver-α-cell axis in mice with liver-specific ablation of the Hepatocyte Nuclear Factor 4α (Hnf4a) gene
Thymiakou E, Tzardi M, Kardassis D
Metabolism . 2022 Dec; 139:155371. PMID: 36464036
Background: Hnf4a gene ablation in mouse liver causes hepatic steatosis, perturbs HDL structure and function and affects many pathways and genes related to glucose metabolism. Our aim here was to...
8.
Using adenovirus-mediated gene transfer to study the effect of myeloperoxidase on plasma lipid levels, HDL structure and functionality in mice expressing human apoA-I forms
Dalakoura-Karagkouni K, Tiniakou I, Zannis V, Kardassis D
Biochem Biophys Res Commun . 2022 Jul; 622:108-114. PMID: 35843089
Apolipoprotein A-I (apoA-I), the main protein component of High-Density Lipoprotein (HDL), is modified in plasma and the arterial wall by various enzymes. Myeloperoxidase (MPO), a leukocyte-derived peroxidase, is highly expressed...
9.
Intestine-specific ablation of the Hepatocyte Nuclear Factor 4a (Hnf4a) gene in mice has minimal impact on serum lipids and ileum gene expression profile due to upregulation of its paralog Hnf4g
Thymiakou E, Xenikaki E, Kardassis D
Biochim Biophys Acta Mol Cell Biol Lipids . 2022 Jan; 1867(3):159108. PMID: 34973414
Ablation of the gene encoding the nuclear receptor Hepatocyte Nuclear Factor 4a (Hnf4a) in the liver strongly affects HDL concentration, structure and functionality but the role of this receptor in...
10.
Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK
Valanti E, Dalakoura-Karagkouni K, Fotakis P, Vafiadaki E, Mantzoros C, Chroni A, et al.
Metabolism . 2021 Dec; 127:154954. PMID: 34875308
Introduction: Atherosclerotic Coronary Artery Disease (ASCAD) is the leading cause of mortality worldwide. Novel therapeutic approaches aiming to improve the atheroprotective functions of High Density Lipoprotein (HDL) include the use...