Diego Sbrissa
Overview
Explore the profile of Diego Sbrissa including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
1064
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Recent Articles
1.
Radoiu C, Govindarajan B, Wang M, Sbrissa D, Cher M, Chinni S
Med Res Arch
. 2024 Jan;
11(7.1).
PMID: 38239314
Prostate cancer commonly metastasizes to bone due to its favorable microenvironment for cell growth and survival. Currently, the standard of care for metastatic prostate cancer is medical castration in conjunction...
2.
Govindarajan B, Sbrissa D, Pressprich M, Kim S, Rishi A, Vaishampayan U, et al.
Sci Rep
. 2023 Nov;
13(1):20634.
PMID: 37996444
The chemokine receptor, CXCR4 signaling regulates cell growth, invasion, and metastasis to the bone-marrow niche in prostate cancer (PCa). Previously, we established that CXCR4 interacts with phosphatidylinositol 4-kinase IIIα (PI4KIIIα...
3.
Govindarajan B, Sbrissa D, Pressprich M, Kim S, Vaishampayan U, Cher M, et al.
Res Sq
. 2023 Mar;
PMID: 36865146
The chemokine receptor, CXCR4 signaling regulates cell growth, invasion, and metastasis to the bone-marrow niche in prostate cancer (PCa). Previously, we established that CXCR4 interacts with phosphatidylinositol 4-kinase IIIα (PI4KIIIα...
4.
Ikonomov O, Sbrissa D, Shisheva A
Toxicol Appl Pharmacol
. 2019 Oct;
383:114771.
PMID: 31628917
Through synthesis of two rare phosphoinositides, PtdIns(3,5)P and PtdIns5P, the ubiquitously expressed phosphoinositide kinase PIKfyve is implicated in pleiotropic cellular functions. Small molecules specifically inhibiting PIKfyve activity cause cytoplasmic vacuolation...
5.
Shisheva A, Sbrissa D, Hu B, Li J
Mol Neurobiol
. 2019 Jul;
56(12):8656-8667.
PMID: 31313076
Charcot-Marie-Tooth disease type-4J (CMT4J), an autosomal recessively inherited peripheral neuropathy characterized by neuronal degeneration, segmental demyelination, and limb muscle weakness, is caused by compound heterozygous mutations in the SAC3/FIG4 gene,...
6.
Sbrissa D, Naisan G, Ikonomov O, Shisheva A
PLoS One
. 2018 Sep;
13(9):e0204532.
PMID: 30240452
PIKfyve, an evolutionarily conserved kinase synthesizing PtdIns5P and PtdIns(3,5)P2, is crucial for mammalian cell proliferation and viability. Accordingly, PIKfyve inhibitors are now in clinical trials as anti-cancer drugs. Among those,...
7.
Sbrissa D, Semaan L, Govindarajan B, Li Y, Caruthers N, Stemmer P, et al.
Oncogene
. 2018 Aug;
38(3):332-344.
PMID: 30111818
Chemokine signaling regulates cell migration and tumor metastasis. CXCL12, a member of the chemokine family, and its receptor, CXCR4, a G protein coupled receptor (GPCR), are key mediators of prostate-cancer...
8.
Ikonomov O, Altankov G, Sbrissa D, Shisheva A
Toxicol Appl Pharmacol
. 2018 Aug;
356:151-158.
PMID: 30098992
PIKfyve phosphoinositide kinase produces PtdIns(3,5)P and PtdIns5P and governs a myriad of cellular processes including cytoskeleton rearrangements and cell proliferation. The latter entails rigorous investigation since the cytotoxicity of PIKfyve...
9.
Compton L, Ikonomov O, Sbrissa D, Garg P, Shisheva A
Am J Physiol Cell Physiol
. 2016 Jun;
311(3):C366-77.
PMID: 27335171
The two evolutionarily conserved mammalian lipid kinases Vps34 and PIKfyve are involved in an important physiological relationship, whereby the former produces phosphatidylinositol (PtdIns) 3P that is used as a substrate...
10.
Ikonomov O, Sbrissa D, Delvecchio K, Rillema J, Shisheva A
Physiol Rep
. 2016 Jun;
4(11).
PMID: 27273882
Systemic deficiency of PIKfyve, the evolutionarily conserved phosphoinositide kinase synthesizing cellular PtdIns5P and PtdIns(3,5)P2 and implicated in insulin signaling, causes early embryonic death in mice. In contrast, mice with muscle-specific...