Diego Morales-Scheihing
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Explore the profile of Diego Morales-Scheihing including associated specialties, affiliations and a list of published articles.
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12
Citations
479
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Recent Articles
1.
Huang H, Wang S, Fang G, Chou W, Liao C, Sun C, et al.
J Med Virol
. 2023 Jan;
95(2):e28478.
PMID: 36609964
Patients with severe COVID-19 often suffer from lymphopenia, which is linked to T-cell sequestration, cytokine storm, and mortality. However, it remains largely unknown how severe acute respiratory syndrome coronavirus 2...
2.
Kusic D, Heil J, Zajic S, Brangan A, Dairo O, Smith G, et al.
Pharmaceutics
. 2022 Sep;
14(9).
PMID: 36145611
Pharmacogenetics (PGx) has the potential to improve opioid medication management. Here, we present patient perception data, pharmacogenetic data and medication management trends in patients with chronic pain (arm 1) and...
3.
Urayama A, Moreno-Gonzalez I, Morales-Scheihing D, Kharat V, Pritzkow S, Soto C
Mol Psychiatry
. 2022 Jul;
27(10):4285-4296.
PMID: 35835859
Alzheimer's disease (AD) is the major form of dementia in the elderly population. The main neuropathological changes in AD patients are neuronal death, synaptic alterations, brain inflammation, and the presence...
4.
Maniskas M, Mack A, Morales-Scheihing D, Finger C, Zhu L, Paulter R, et al.
Brain Behav Immun Health
. 2021 Sep;
14:100260.
PMID: 34589766
Cerebral amyloid angiopathy (CAA) is one of the common causes of lobar intracerebral hemorrhage and vascular cognitive impairment (VCI) in the aging population. Increased amyloid plaque deposition within cerebral blood...
5.
Morales R, Duran-Aniotz C, Bravo-Alegria J, Estrada L, Shahnawaz M, Hu P, et al.
Acta Neuropathol Commun
. 2020 Dec;
8(1):213.
PMID: 33287898
Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ) aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer's disease (AD) through prion-like mechanisms. In this...
6.
Holmes A, Finger C, Morales-Scheihing D, Lee J, McCullough L
Transl Res
. 2020 Aug;
226:39-56.
PMID: 32755639
The gut microbiota is a complex ecosystem of bacteria, fungi, and viruses that acts as a critical regulator in microbial, metabolic, and immune responses in the host organism. Imbalances in...
7.
Furr J, Morales-Scheihing D, Manwani B, Lee J, McCullough L
Neuromolecular Med
. 2019 Oct;
21(4):369-390.
PMID: 31586276
The protein molecules must fold into unique conformations to acquire functional activity. Misfolding, aggregation, and deposition of proteins in diverse organs, the so-called "protein misfolding disorders (PMDs)", represent the conformational...
8.
Ritzel R, Lai Y, Crapser J, Patel A, Schrecengost A, Grenier J, et al.
Acta Neuropathol
. 2018 May;
136(1):89-110.
PMID: 29752550
The peripheral immune system plays a critical role in aging and in the response to brain injury. Emerging data suggest inflammatory responses are exacerbated in older animals following ischemic stroke;...
9.
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
Mukherjee A, Morales-Scheihing D, Salvadores N, Moreno-Gonzalez I, Gonzalez C, Taylor-Presse K, et al.
J Exp Med
. 2017 Aug;
214(9):2591-2610.
PMID: 28765400
Although a large proportion of patients with type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown. Here, we...
10.
Mukherjee A, Morales-Scheihing D, Butler P, Soto C
Trends Mol Med
. 2015 May;
21(7):439-49.
PMID: 25998900
Type 2 diabetes (T2D) is a highly prevalent and chronic metabolic disorder. Recent evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) might contribute to β-cell...