Type 2 Diabetes As a Protein Misfolding Disease

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2015 May 23

PMID 25998900

Citations 130

Authors

Abhisek Mukherjee

Diego Morales-Scheihing

Peter C Butler

Claudio Soto

Affiliations

Soon will be listed here.

Abstract

Type 2 diabetes (T2D) is a highly prevalent and chronic metabolic disorder. Recent evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) might contribute to β-cell dysfunction and disease. However, the mechanism of protein aggregation and associated toxicity remains unclear. Misfolding, aggregation, and accumulation of diverse proteins in various organs is the hallmark of the group of protein misfolding disorders (PMDs), including highly prevalent illnesses affecting the central nervous system (CNS) such as Alzheimer's disease (AD) and Parkinson's disease (PD). In this review we discuss the current understanding of the mechanisms implicated in the formation of protein aggregates in the endocrine pancreas and associated toxicity in the light of the long-standing knowledge from neurodegenerative disorders associated with protein misfolding.

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