Diederik van Bodegom
Overview
Explore the profile of Diederik van Bodegom including associated specialties, affiliations and a list of published articles.
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10
Citations
577
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Recent Articles
1.
Jacobson C, Kopp N, Layer J, Redd R, Tschuri S, Haebe S, et al.
Blood
. 2016 Oct;
128(21):2517-2526.
PMID: 27742706
The Bruton tyrosine kinase (BTK) inhibitor ibrutinib induces responses in 70% of patients with relapsed and refractory mantle cell lymphoma (MCL). Intrinsic resistance can occur through activation of the nonclassical...
2.
Wu S, Li L, Kopp N, Montero J, Chapuy B, Yoda A, et al.
Cancer Cell
. 2015 Jul;
28(1):29-41.
PMID: 26175414
A variety of cancers depend on JAK2 signaling, including the high-risk subset of B cell acute lymphoblastic leukemias (B-ALLs) with CRLF2 rearrangements. Type I JAK2 inhibitors induce paradoxical JAK2 hyperphosphorylation...
3.
Lane A, Chapuy B, Lin C, Tivey T, Li H, Townsend E, et al.
Nat Genet
. 2014 Apr;
46(6):618-23.
PMID: 24747640
Down syndrome confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (B-ALL), and polysomy 21 is the most frequent somatic aneuploidy among all B-ALLs. Yet the mechanistic links...
4.
Zhong J, Sharma J, Raju R, Palapetta S, Keshava Prasad T, Huang T, et al.
Database (Oxford)
. 2014 Feb;
2014:bau007.
PMID: 24573880
Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through...
5.
Odejide O, Weigert O, Lane A, Toscano D, Lunning M, Kopp N, et al.
Blood
. 2013 Dec;
123(9):1293-6.
PMID: 24345752
The genetics of angioimmunoblastic T-cell lymphoma (AITL) are very poorly understood. We defined the mutational landscape of AITL across 219 genes in 85 cases from the United States and Europe....
6.
van Bodegom D, Zhong J, Kopp N, Dutta C, Kim M, Bird L, et al.
Blood
. 2012 Aug;
120(14):2853-63.
PMID: 22915648
Approximately 10% of B-cell acute lymphoblastic leukemias (B-ALLs) overexpress the cytokine receptor subunit CRLF2, which may confer a poor prognosis. CRLF2 binds its ligand thymic stromal lymphopoietin (TSLP) as a...
7.
Dutta C, Day T, Kopp N, van Bodegom D, Davids M, Ryan J, et al.
Cancer Res
. 2012 Jun;
72(16):4193-203.
PMID: 22689920
BCL2 suppresses apoptosis by binding the BH3 domain of proapoptotic factors and thereby regulating outer mitochondrial membrane permeabilization. Many tumor types, including B-cell lymphomas and chronic lymphocytic leukemia, are dependent...
8.
Weigert O, Lane A, Bird L, Kopp N, Chapuy B, van Bodegom D, et al.
J Exp Med
. 2012 Jan;
209(2):259-73.
PMID: 22271575
Enzymatic inhibitors of Janus kinase 2 (JAK2) are in clinical development for the treatment of myeloproliferative neoplasms (MPNs), B cell acute lymphoblastic leukemia (B-ALL) with rearrangements of the cytokine receptor...
9.
van Bodegom D, Roessingh W, Pridjian A, El Dahr S
Biochim Biophys Acta
. 2010 Apr;
1799(7):502-9.
PMID: 20388565
We previously reported that the tumor suppressor protein p53 participates in a negative feedback loop to fine-tune PKD1 gene expression. This physiological pathway is believed to prevent polycystin-1 overexpression and...
10.
van Bodegom D, Saifudeen Z, Dipp S, Puri S, Magenheimer B, Calvet J, et al.
J Biol Chem
. 2006 Aug;
281(42):31234-44.
PMID: 16931520
This study provides evidence that the tumor suppressor protein, p53, is a transcriptional repressor of PKD1. Kidneys of p53-null mice expressed higher Pkd1 mRNA levels than wild-type littermates; gamma-irradiation suppressed...