Dianer Yang
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Explore the profile of Dianer Yang including associated specialties, affiliations and a list of published articles.
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17
Citations
415
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Recent Articles
1.
Brain-targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic-ischemic brain injury
Kuan C, Chen H, Gao N, Kuo Y, Chen C, Yang D, et al.
Neurobiol Dis
. 2020 Nov;
148:105200.
PMID: 33248237
Hypoxia-inducible factor-1α (HIF1α) is a major regulator of cellular adaptation to hypoxia and oxidative stress, and recent advances of prolyl-4-hydroxylase (P4H) inhibitors have produced powerful tools to stabilize HIF1α for...
2.
Wu J, Sabirzhanov B, Stoica B, Lipinski M, Zhao Z, Zhao S, et al.
Cell Cycle
. 2015 Oct;
14(23):3698-712.
PMID: 26505089
Traumatic spinal cord injury (SCI) induces cell cycle activation (CCA) that contributes to secondary injury and related functional impairments such as motor deficits and hyperpathia. E2F1 and E2F2 are members...
3.
Yang D, Kuan C
CNS Neurosci Ther
. 2014 Dec;
21(4):367-73.
PMID: 25475942
Hypoxic-ischemic brain injury is an important cause of neurodevelopmental deficits in neonates. Intrauterine infection and the ensuing fetal inflammatory responses augment hypoxic-ischemic brain injury and attenuate the efficacy of therapeutic...
4.
Yang D, Sun Y, Bhaumik S, Li Y, Baumann J, Lin X, et al.
J Neurosci
. 2014 Dec;
34(49):16467-81.
PMID: 25471584
Intrauterine infection (chorioamnionitis) aggravates neonatal hypoxic-ischemic (HI) brain injury, but the mechanisms linking systemic inflammation to the CNS damage remain uncertain. Here we report evidence for brain influx of T-helper...
5.
Sun Y, Morozov Y, Yang D, Li Y, Dunn R, Rakic P, et al.
PLoS One
. 2014 Jun;
9(6):e98807.
PMID: 24911517
Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of tissue plasminogen activator (tPA) in preclinical models. However,...
6.
Yang D, Sun Y, Lin X, Baumann J, Warnock M, Lawrence D, et al.
Stroke
. 2013 Jul;
44(9):2623-2627.
PMID: 23881953
Background And Purpose: Plasminogen activator inhibitor-I (PAI-1), a ≈50-kDa serine protease inhibitor, markedly reduces the extravascular toxicity of tissue-type plasminogen activator in experimental hypoxic-ischemic (HI) brain injury of newborns. However,...
7.
Yang D, Baumann J, Sun Y, Tang M, Dunn R, Akeson A, et al.
Sci Transl Med
. 2013 Jul;
5(193):193ra90.
PMID: 23843451
Intracranial hemorrhage in preterm neonates may result in neonatal mortality and functional disabilities, but its pathogenic mechanisms are poorly defined and better therapies are needed. We used a tetracycline-regulated transgenic...
8.
Lopez-Juarez A, Howard J, Ullom K, Howard L, Grande A, Pardo A, et al.
Genes Dev
. 2013 Jun;
27(11):1272-87.
PMID: 23723414
Neural stem cells (NSCs) reside in widespread regions along the lateral ventricle and generate diverse olfactory bulb (OB) interneuron subtypes in the adult mouse brain. Molecular mechanisms underlying their regional...
9.
Yang D, Sun Y, Lin X, Baumann J, Dunn R, Lindquist D, et al.
Exp Neurol
. 2013 Jan;
247:447-455.
PMID: 23353638
Perinatal infection aggravates neonatal hypoxic-ischemic (HI) brain injury and may interfere with therapeutic hypothermia. While the NF-κB signaling pathway has been implicated in microglia activation in infection-sensitized HI, the current...
10.
Yang D, Sun Y, Nemkul N, Baumann J, Shereen A, Dunn R, et al.
Cereb Cortex
. 2012 May;
23(5):1218-29.
PMID: 22556277
Intrauterine infection exacerbates neonatal hypoxic-ischemic (HI) brain injury and impairs the development of cerebral cortex. Here we used low-dose lipopolysaccharide (LPS) pre-exposure followed by unilateral cerebral HI insult in 7-day-old...