Dheeraj Malhotra
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Explore the profile of Dheeraj Malhotra including associated specialties, affiliations and a list of published articles.
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45
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6453
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Recent Articles
1.
Haglund A, Zuber V, Abouzeid M, Yang Y, Ko J, Wiemann L, et al.
Nat Genet
. 2025 Jan;
57(2):358-368.
PMID: 39794547
Gene expression quantitative trait loci are widely used to infer relationships between genes and central nervous system (CNS) phenotypes; however, the effect of brain disease on these inferences is unclear....
2.
Macnair W, Calini D, Agirre E, Bryois J, Jakel S, Smith R, et al.
Neuron
. 2024 Dec;
113(3):396-410.e9.
PMID: 39708806
Poor understanding of the cellular and molecular basis of clinical and genetic heterogeneity in progressive multiple sclerosis (MS) has hindered the search for new effective therapies. To address this gap,...
3.
Rexach J, Cheng Y, Chen L, Polioudakis D, Lin L, Mitri V, et al.
Cell
. 2024 Sep;
187(20):5753-5774.e28.
PMID: 39265576
The development of successful therapeutics for dementias requires an understanding of their shared and distinct molecular features in the human brain. We performed single-nuclear RNA-seq and ATAC-seq in Alzheimer's disease...
4.
Gaur P, Bryois J, Calini D, Foo L, Hoozemans J, Malhotra D, et al.
bioRxiv
. 2024 May;
PMID: 38712204
Alzheimer's disease (AD) is a neurodegenerative disorder with complex pathological manifestations and is the leading cause of cognitive decline and dementia in elderly individuals. A major goal in AD research...
5.
Rexach J, Cheng Y, Chen L, Polioudakis D, Lin L, Mitri V, et al.
bioRxiv
. 2023 Oct;
PMID: 37808727
The development of successful therapeutics for dementias requires an understanding of their shared and distinct molecular features in the human brain. We performed single-nuclear RNAseq and ATACseq in Alzheimer disease...
6.
Touil H, Roostaei T, Calini D, Diaconu C, Epstein S, Raposo C, et al.
Cell Rep Methods
. 2023 Aug;
3(7):100533.
PMID: 37533636
Single-cell transcriptomics allows characterization of cerebrospinal fluid (CSF) cells at an unprecedented level. Here, we report a robust cryopreservation protocol adapted for the characterization of fragile CSF cells by single-cell...
7.
Liu D, Meyer D, Fennessy B, Feng C, Cheng E, Johnson J, et al.
Nat Genet
. 2023 Mar;
55(3):369-376.
PMID: 36914870
Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of the protein-coding regions of the genome identified...
8.
Corominas R, Yang X, Lin G, Kang S, Shen Y, Ghamsari L, et al.
Nat Commun
. 2023 Feb;
14(1):569.
PMID: 36732511
No abstract available.
9.
Bryois J, Calini D, Macnair W, Foo L, Urich E, Ortmann W, et al.
Nat Neurosci
. 2022 Aug;
25(8):1104-1112.
PMID: 35915177
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic variants contribute to gene expression, have been performed in heterogeneous brain tissues rather than specific cell types....
10.
Trubetskoy V, Pardinas A, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli T, et al.
Nature
. 2022 Apr;
604(7906):502-508.
PMID: 35396580
Schizophrenia has a heritability of 60-80%, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and...