Dhanush Haspula
Overview
Explore the profile of Dhanush Haspula including associated specialties, affiliations and a list of published articles.
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13
Citations
187
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Recent Articles
1.
Pittala S, Haspula D, Cui Y, Yang W, Kim Y, Davis R, et al.
Nat Commun
. 2024 Nov;
15(1):9996.
PMID: 39557854
Altered hepatic glucose fluxes are critical during the pathogenesis of type 2 diabetes. G protein-coupled receptors represent important regulators of hepatic glucose production. Recent studies have shown that hepatocytes express...
2.
Alanazi A, Alhazzani K, Alrewily S, Aljerian K, Algahtani M, Alqahtani Q, et al.
Pharmaceuticals (Basel)
. 2023 Jul;
16(7).
PMID: 37513833
Dasatinib (DASA) is a novel tyrosine kinase inhibitor, approved for leukemia treatment. However, the long-term use of DASA induces several complications, especially liver damage. On the other hand, Naringenin (NGN)...
3.
Haspula D, Cui Z
Cells
. 2023 Jul;
12(13).
PMID: 37443835
Precise neural regulation is required for maintenance of energy homeostasis. Essential to this are the hypothalamic and brainstem nuclei which are located adjacent and supra-adjacent to the circumventricular organs. They...
4.
Oconnor A, Haspula D, Alanazi A, Clark M
Peptides
. 2022 Apr;
153:170802.
PMID: 35489649
Angiotensin (Ang) III, a biologically active peptide of the renin angiotensin system (RAS) is predominantly known for its central effects on blood pressure. Our understanding of the RAS has evolved...
5.
Kimura T, Pydi S, Wang L, Haspula D, Cui Y, Lu H, et al.
Nat Commun
. 2022 Mar;
13(1):1652.
PMID: 35351896
Obesity is the major driver of the global epidemic in type 2 diabetes (T2D). In individuals with obesity, impaired insulin action leads to increased lipolysis in adipocytes, resulting in elevated...
6.
Haspula D, Clark M
Molecules
. 2021 Jun;
26(10).
PMID: 34069330
Angiotensin (Ang) II is well-known to have potent pro-oxidant and pro-inflammatory effects in the brain. Extensive crosstalk between the primary Ang II receptor, Ang type 1 receptor (AT1R), and the...
7.
Haspula D, Clark M
Int J Mol Sci
. 2020 Oct;
21(20).
PMID: 33080916
The identification of the human cannabinoid receptors and their roles in health and disease, has been one of the most significant biochemical and pharmacological advancements to have occurred in the...
8.
Haspula D, Vallejos A, Moore T, Tomar N, Dash R, Hoffmann B
Front Physiol
. 2019 May;
10:558.
PMID: 31133884
Hyperglycemia is a critical factor in the development of endothelial dysfunction in type 2 diabetes mellitus (T2DM). Whether hyperglycemic states result in a disruption of similar molecular mechanisms in endothelial...
9.
Haspula D, Clark M
J Pharmacol Exp Ther
. 2018 May;
366(2):251-264.
PMID: 29752427
The central renin angiotensin system (RAS) is one of the most widely investigated cardiovascular systems in the brain. It is implicated in a myriad of cardiovascular diseases. However, studies from...
10.
Haspula D, Clark M
Auton Neurosci
. 2018 Jan;
210:10-17.
PMID: 29361405
Essential hypertension is a multifactorial disorder with a strong genetic predisposition. Although anti-hypertensive medications have drastically reduced cardiovascular diseases mortality and morbidity rates, a significant percentage of hypertensive individuals currently...