Dewey G McCafferty
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Explore the profile of Dewey G McCafferty including associated specialties, affiliations and a list of published articles.
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54
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1408
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Recent Articles
1.
Hatstat A, Quan B, Bailey M, Fitzgerald M, Reinhart M, McCafferty D
RSC Chem Biol
. 2022 Feb;
3(1):96-111.
PMID: 35128413
The development of phenotypic models of Parkinson's disease (PD) has enabled screening and identification of phenotypically active small molecules that restore complex biological pathways affected by PD toxicity. While these...
2.
Dudiak B, Nguyen T, Needham D, Outlaw T, McCafferty D
FEBS Lett
. 2021 Nov;
595(24):2995-3005.
PMID: 34741525
Chlamydia trachomatis, an obligate intracellular bacterium with limited metabolic capabilities, possesses the futalosine pathway for menaquinone biosynthesis. Futalosine pathway enzymes have promise as narrow-spectrum antibiotic targets, but the activity and...
3.
Hatstat A, Pupi M, Reinhart M, McCafferty D
ACS Chem Neurosci
. 2021 Oct;
12(21):3972-3984.
PMID: 34652126
Disrupted cellular trafficking and transport processes are hallmarks of many neurodegenerative disorders (NDs). Recently, efforts have been made toward developing and implementing experimental platforms to identify small molecules that may...
4.
Hatstat A, Pupi M, McCafferty D
PLoS One
. 2021 Oct;
16(10):e0258315.
PMID: 34637467
The Nedd4 family contains several structurally related but functionally distinct HECT-type ubiquitin ligases. The members of the Nedd4 family are known to recognize substrates through their multiple WW domains, which...
5.
Stariha L, McCafferty D
Chembiochem
. 2021 Jun;
22(16):2632-2640.
PMID: 34133845
Lasso peptides are a structurally diverse superfamily of conformationally constrained peptide natural products, of which a subset exhibits broad antimicrobial activity. Although advances in bioinformatics have increased our knowledge of...
6.
Hatstat A, Ahrendt H, Foster M, Mayne L, Moseley M, Englander S, et al.
Cell Chem Biol
. 2020 Nov;
28(1):14-25.e9.
PMID: 33176158
The benzdiimidazole NAB2 rescues α-synuclein-associated trafficking defects associated with early onset Parkinson's disease in a Nedd4-dependent manner. Despite identification of E3 ubiquitin ligase Nedd4 as a putative target of NAB2,...
7.
Morgan K, Zheng J, McCafferty D
Chembiochem
. 2020 Aug;
22(1):176-185.
PMID: 32805078
Ramoplanins and enduracidins are peptidoglycan lipid intermediate II-binding lipodepsipeptides with broad-spectrum activity against methicillin- and vancomycin-resistant Gram-positive pathogens. Targeted genome mining using probes from conserved sequences within the ramoplanin/enduracidin biosynthetic...
8.
Hatstat A, McCafferty D
Protein Expr Purif
. 2020 Apr;
173:105649.
PMID: 32334140
Nedd4 is an E3 ubiquitin ligase that has received increased attention due to its role in the maintenance of proteostasis and in cellular stress responses. Investigation of Nedd4 enzymology has...
9.
Dudiak B, Maksimchuk K, Bednar M, Podracky C, Burg J, Nguyen T, et al.
Biochemistry
. 2019 Aug;
58(33):3527-3536.
PMID: 31386347
CPAF (chlamydial protease-like activity factor) is a protease that is translocated into the host cytosol during infection. CPAF activity results in dampened host inflammation signaling, cytoskeletal remodeling, and suppressed neutrophil...
10.
Biniossek M, Niemer M, Maksimchuk K, Mayer B, Fuchs J, Huesgen P, et al.
Mol Cell Proteomics
. 2016 Apr;
15(7):2515-24.
PMID: 27122596
We present protease specificity profiling based on quantitative proteomics in combination with proteome-derived peptide libraries. Peptide libraries are generated by endoproteolytic digestion of proteomes without chemical modification of primary amines...