Devika S Manickam
Overview
Explore the profile of Devika S Manickam including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
635
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Recent Articles
11.
Khare P, Conway J, Manickam D
Eur J Pharm Biopharm
. 2022 Oct;
180:238-250.
PMID: 36265829
Lipidoid nanoparticles (LNPs) are clinically successful carriers for nucleic acid delivery to liver and muscle targets. The ability of LNPs to load and deliver small molecule drugs has not been...
12.
Manickam D
J Control Release
. 2022 Feb;
343:400-407.
PMID: 35131369
The field of drug delivery has made tremendous advances in increasing the therapeutic potential of a variety of drug candidates spanning from small molecules to large molecular biologics such as...
13.
Khare P, Dave K, Kamte Y, Manoharan M, ODonnell L, Manickam D
AAPS J
. 2021 Dec;
24(1):8.
PMID: 34873640
Lipidoid nanoparticles (LNPs) are the delivery platform in Onpattro, the first FDA-approved siRNA drug. LNPs are also the carriers in the Pfizer-BioNTech and Moderna COVID-19 mRNA vaccines. While these applications...
14.
DSouza A, Burch A, Dave K, Sreeram A, Reynolds M, Dobbins D, et al.
J Control Release
. 2021 Aug;
338:505-526.
PMID: 34450196
We have demonstrated, for the first time that microvesicles, a sub-type of extracellular vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer polarized mitochondria to recipient...
15.
DSouza A, Dave K, Stetler R, Manickam D
Adv Drug Deliv Rev
. 2021 Jan;
171:332-351.
PMID: 33497734
A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier (BBB) are emerging...
16.
Extracellular Vesicles Derived from a Human Brain Endothelial Cell Line Increase Cellular ATP Levels
Dave K, Zhao W, Hoover C, DSouza A, Manickam D
AAPS PharmSciTech
. 2021 Jan;
22(1):18.
PMID: 33389284
Engineered cell-derived extracellular vesicles (EVs) such as exosomes and microvesicles hold immense potential as safe and efficient drug carriers due to their lower immunogenicity and inherent homing capabilities to target...
17.
Dave K, Han L, Jackson M, Kadlecik L, Duvall C, Manickam D
Pharm Res
. 2020 Aug;
37(9):176.
PMID: 32860072
Purpose: We tested polyplexes of a diblock polymer containing a pH-responsive, endosomolytic core (dimethylaminoethyl methacrylate and butyl methacrylate; DB) and a zwitterionic Poly (methacryloyloxyethyl phosphorylcholine) (PMPC) corona for the delivery...
18.
Dave K, Ali L, Manickam D
PLoS One
. 2020 Apr;
15(4):e0231597.
PMID: 32287325
Resident microglia of the central nervous system are being increasingly recognized as key players in diseases such as neuropathic pain. Biochemical and behavioral studies in neuropathic pain rodent models have...
19.
Zhao W, Han L, Bae Y, Manickam D
J Vis Exp
. 2019 Sep;
(150).
PMID: 31475964
The blood-brain barrier BBB consists of endothelial cells that form a barrier between the systemic circulation and the brain to prevent the exchange of non-essential ions and toxic substances. Tight...
20.
Jiang Y, Fay J, Poon C, Vinod N, Zhao Y, Bullock K, et al.
Adv Funct Mater
. 2018 May;
28(6).
PMID: 29785179
Brain-derived neurotrophic factor (BDNF) is identified as a potent neuroprotective and neuroregenerative agent for many neurological diseases. Regrettably, its delivery to the brain is hampered by poor serum stability and...