Derk J Hogenkamp
Overview
Explore the profile of Derk J Hogenkamp including associated specialties, affiliations and a list of published articles.
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17
Citations
237
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Recent Articles
1.
Manville R, Foglia L, Yoshimura R, Hogenkamp D, Nguyen A, Yu A, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(2):e2411816122.
PMID: 39793113
Loss-of-function sequence variants in , which encodes the voltage-gated potassium channel Kv1.1, cause Episodic Ataxia Type 1 (EA1) and epilepsy. Due to a paucity of drugs that directly rescue mutant...
2.
Manville R, Redford K, van der Horst J, Hogenkamp D, Jepps T, Abbott G
FASEB J
. 2022 Aug;
36(9):e22457.
PMID: 35997997
Tree and shrub barks have been used as folk medicine by numerous cultures across the globe for millennia, for a variety of indications, including as vasorelaxants and antispasmodics. Here, using...
3.
Johnstone T, Xie J, Qu C, Wasiak D, Hogenkamp D, Porreca F, et al.
Pain
. 2018 Sep;
160(1):198-209.
PMID: 30204648
Chronic neuropathic pain may be caused, in part, by loss of inhibition in spinal pain processing pathways due to attenuation of local GABAergic tone. Nociception and nocifensive behaviors are reduced...
4.
Reddy D, Yoshimura R, Ramanathan G, Carver C, Johnstone T, Hogenkamp D, et al.
Epilepsy Behav
. 2018 Mar;
82:57-63.
PMID: 29587186
Objective: Subunit-specific positive allosteric modulators (PAMs) of gamma-aminobutyric acid-A (GABA-A) receptors are commonly used to uncover the role of GABA-A receptor isoforms in brain function. Recently, we have designed novel...
5.
Yoshimura R, Tran M, Hogenkamp D, Ayala N, Johnstone T, Dunnigan A, et al.
Neuropharmacology
. 2017 Aug;
126:38-47.
PMID: 28842344
Autism spectrum disorder (ASD) is associated with two core symptoms (social communication deficits and stereotyped repetitive behaviors) in addition to a number of comorbidities. There are no FDA-approved drugs for...
6.
Hogenkamp D, Tran M, Yoshimura R, Johnstone T, Kanner R, Gee K
Psychopharmacology (Berl)
. 2014 Apr;
231(17):3517-24.
PMID: 24682501
Rationale: In order to improve upon the pharmacological properties of the neuroactive steroid ganaxolone, it was used as the starting point in the design of novel neurosteroids that replace the...
7.
Yoshimura R, Tran M, Hogenkamp D, Johnstone T, Xie J, Porreca F, et al.
J Psychopharmacol
. 2013 Oct;
28(5):472-8.
PMID: 24108410
GABAergic anxiolytics have well-documented centrally mediated side effects including sedation, potentiation of ethanol, tolerance, abuse liability and memory impairment. Most research directed towards identifying an anxioselective GABAergic therapeutic has been...
8.
Hogenkamp D, Ford-Hutchinson T, Li W, Whittemore E, Yoshimura R, Tran M, et al.
J Med Chem
. 2013 Oct;
56(21):8352-65.
PMID: 24098954
A series of novel arylpyrid-3-ylmethanones (7a-aa) were designed as modulators of α7 nicotinic acetylcholine receptors (nAChRs). The methanones were found to be type I positive allosteric modulators (PAMs) of human...
9.
Lotfipour S, Arnold M, Hogenkamp D, Gee K, Belluzzi J, Leslie F
Neuropharmacology
. 2011 Mar;
61(1-2):95-104.
PMID: 21419142
Our current study aims to evaluate the mechanisms of tranylcypromine (TCP)-mediated enhancement of nicotine self-administration. We replicated our previous findings which demonstrate that 1 h pretreatment with TCP (3 mg/kg,...
10.
Johnstone T, Gu Z, Yoshimura R, Villegier A, Hogenkamp D, Whittemore E, et al.
J Pharmacol Exp Ther
. 2010 Dec;
336(3):908-15.
PMID: 21159751
α5 Subunit-containing GABA(A) receptors (GABA(A)Rs) and α7 neuronal nicotinic-acetylcholine receptors (nAChRs) are members of the Cys-loop family of ligand-gated ion channels (LGICs) that mediate cognitive and attentional processes in the...