Derek B McMahon
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Explore the profile of Derek B McMahon including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
218
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Recent Articles
1.
Miller Z, Mueller A, Kim T, Jolivert J, Ma R, Muthuswami S, et al.
Cell Rep
. 2023 Nov;
42(12):113437.
PMID: 37995679
Head and neck squamous cell carcinomas (HNSCCs) have high mortality and significant treatment-related morbidity. It is vital to discover effective, minimally invasive therapies that improve survival and quality of life....
2.
McMahon D, Jolivert J, Kuek L, Adappa N, Palmer J, Lee R
Nutrients
. 2023 Feb;
15(3).
PMID: 36771227
Human airway sweet (T1R2 + T1R3), umami (T1R1 + T1R3), and bitter taste receptors (T2Rs) are critical components of the innate immune system, acting as sensors to monitor pathogenic growth....
3.
McMahon D, Jolivert J, Kuek L, Adappa N, Palmer J, Lee R
Nutrients
. 2023 Feb;
15(3).
PMID: 36771200
T1Rs are expressed in solitary chemosensory cells of the upper airway where they detect apical glucose levels and repress bitter taste receptor Ca signaling pathways. Microbial growth leads to a...
4.
Kuek L, McMahon D, Ma R, Miller Z, Jolivert J, Adappa N, et al.
Pharmaceuticals (Basel)
. 2022 Apr;
15(4).
PMID: 35455449
T2R bitter taste receptors in airway motile cilia increase ciliary beat frequency (CBF) and nitric oxide (NO) production. Polymorphisms in some T2Rs are linked to disease outcomes in chronic rhinosinusitis...
5.
McMahon D, Kuek L, Johnson M, Johnson P, Horn R, Carey R, et al.
Cell Calcium
. 2021 Nov;
101:102499.
PMID: 34839223
Bitter taste receptors (T2Rs) localize to airway motile cilia and initiate innate immune responses in retaliation to bacterial quorum sensing molecules. Activation of cilia T2Rs leads to calcium-driven NO production...
6.
Carey R, McMahon D, Miller Z, Kim T, Rajasekaran K, Gopallawa I, et al.
Mol Oncol
. 2021 Oct;
16(7):1474-1492.
PMID: 34717036
Better management of head and neck squamous cell carcinomas (HNSCCs) requires a clearer understanding of tumor biology and disease risk. Bitter taste receptors (T2Rs) have been studied in several cancers,...
7.
McMahon D, Carey R, Kohanski M, Adappa N, Palmer J, Lee R
Am J Physiol Lung Cell Mol Physiol
. 2021 Mar;
320(5):L845-L879.
PMID: 33655758
Airway submucosal gland serous cells are important sites of fluid secretion in conducting airways. Serous cells also express the cystic fibrosis (CF) transmembrane conductance regulator (CFTR). Protease-activated receptor 2 (PAR-2)...
8.
McMahon D, Carey R, Kohanski M, Tong C, Papagiannopoulos P, Adappa N, et al.
Eur Respir J
. 2020 Feb;
55(4).
PMID: 32029445
Airway submucosal gland serous cells are sites of expression of the cystic fibrosis transmembrane conductance regulator (CFTR) and are important for fluid secretion in conducting airways. To elucidate how neuropeptides...
9.
Hariri B, McMahon D, Chen B, Adappa N, Palmer J, Kennedy D, et al.
PLoS One
. 2017 Sep;
12(9):e0185203.
PMID: 28931063
Flavones are a class of natural plant secondary metabolites that have anti-inflammatory and anti-bacterial effects. Some flavones also activate the T2R14 bitter taste receptor, which is expressed in motile cilia...
10.
Lee R, Hariri B, McMahon D, Chen B, Doghramji L, Adappa N, et al.
Sci Signal
. 2017 Sep;
10(495).
PMID: 28874606
In the upper respiratory epithelium, bitter and sweet taste receptors present in solitary chemosensory cells influence antimicrobial innate immune defense responses. Whereas activation of bitter taste receptors (T2Rs) stimulates surrounding...