Derek A Willoughby
Overview
Explore the profile of Derek A Willoughby including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
475
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0
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Recent Articles
1.
Ayoub S, Colville-Nash P, Willoughby D, Botting R
Eur J Pharmacol
. 2006 May;
538(1-3):57-65.
PMID: 16674937
Paracetamol is a widely used analgesic and antipyretic with weak anti-inflammatory properties. Experimental evidence suggests that inhibition of prostaglandin biosynthesis contributes to its pharmacological actions. Three cyclooxygenase (COX) isoenzymes are...
2.
Sawatzky D, Willoughby D, Colville-Nash P, Rossi A
Am J Pathol
. 2006 Jan;
168(1):33-41.
PMID: 16400007
Inflammatory cell recruitment, activation, and apoptosis are highly regulated processes involving several checkpoints controlling the resolution of inflammation. We investigated the role of the mitogen-activated protein kinase (MAPK) signaling pathway...
3.
Colville-Nash P, Gilroy D, Willis D, Paul-Clark M, Moore A, Willoughby D
Inflammopharmacology
. 2005 Nov;
12(5-6):473-6.
PMID: 16259714
Cyclooxygenase-2 may play a role in resolution of carrageenan-induced pleurisy in rats by generating anti-inflammatory prostanoids. Here, we show exudate prostaglandin F2alpha concentrations rise during resolution of this model. These...
4.
Ayoub S, Botting R, Goorha S, Colville-Nash P, Willoughby D, Ballou L
Proc Natl Acad Sci U S A
. 2004 Jul;
101(30):11165-9.
PMID: 15263079
Acetaminophen is a widely used antipyretic analgesic, reducing fever caused by bacterial and viral infections and by clinical trauma such as cancer or stroke. In rare cases in humans, e.g.,...
5.
Gilroy D, Newson J, Sawmynaden P, Willoughby D, Croxtall J
FASEB J
. 2004 Mar;
18(3):489-98.
PMID: 15003994
Acute inflammation can be considered in terms of a series of checkpoints where each phase of cellular influx, persistence, and clearance is controlled by endogenous stop and go signals. It...
6.
Gilroy D, Colville-Nash P, McMaster S, Sawatzky D, Willoughby D, Lawrence T
FASEB J
. 2003 Oct;
17(15):2269-71.
PMID: 14563690
Failure of acute inflammation to resolve leads to persistence of the inflammatory response and may contribute to the development of chronic inflammation. Thus, an understanding of inflammatory resolution will provide...
7.
Brown J, Seed M, Willoughby D
Adv Exp Med Biol
. 2003 Apr;
507:409-14.
PMID: 12664618
No abstract available.
8.
Lawrence T, Willoughby D, Gilroy D
Nat Rev Immunol
. 2002 Oct;
2(10):787-95.
PMID: 12360216
The pro-inflammatory signalling pathways and cellular mechanisms that initiate the inflammatory response have become increasingly well characterized. However, little is known about the mediators and mechanisms that switch off inflammation....
9.
Colville-Nash P, Willoughby D
Biorheology
. 2002 Jun;
39(1-2):171-9.
PMID: 12082280
It is widely accepted that whilst exhibiting clinically useful anti-inflammatory and analgesic activity, the application of non-steroidal anti-inflammatory drugs (NSAIDs) does not affect the underlying pathogenesis of articular diseases such...