Dennis Leung
Overview
Explore the profile of Dennis Leung including associated specialties, affiliations and a list of published articles.
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32
Citations
351
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Recent Articles
1.
Fan Y, Rigas D, Kim L, Chang F, Zang N, McKee K, et al.
J Control Release
. 2024 Jul;
373:727-737.
PMID: 39059500
The surge in RNA therapeutics has revolutionized treatments for infectious diseases like COVID-19 and shows the potential to expand into other therapeutic areas. However, the typical requirement for ultra-cold storage...
2.
Gatti J, Ahmad S, Gardner Yelton S, DiGiusto M, Leung D, Xu R, et al.
J Stroke Cerebrovasc Dis
. 2023 Nov;
33(1):107476.
PMID: 37976795
Objectives: Surgical revascularization for moyamoya arteriopathy decreases long-term stroke risk but carries a risk of perioperative ischemic complications. We aimed to evaluate modifiable stroke risk factors in children undergoing surgical...
3.
He M, Zhu S, Cannon J, Christensen J, Duggal R, Gunduz M, et al.
Drug Metab Dispos
. 2023 Aug;
51(11):1436-1450.
PMID: 37591731
Therapeutic peptides (TPeps) have expanded from the initial endogenous peptides to complex modified peptides through medicinal chemistry efforts for almost a century. Different from small molecules and large proteins, the...
4.
Hammel M, Fan Y, Sarode A, Byrnes A, Zang N, Kou P, et al.
ACS Nano
. 2023 Jun;
17(12):11454-11465.
PMID: 37279108
With three FDA-approved products, lipid nanoparticles (LNPs) are under intensive development for delivering wide-ranging nucleic acid therapeutics. A significant challenge for LNP development is insufficient understanding of structure-activity relationship (SAR)....
5.
Sarode A, Fan Y, Byrnes A, Hammel M, Hura G, Fu Y, et al.
Nanoscale Adv
. 2022 Sep;
4(9):2107-2123.
PMID: 36133441
Lipid nanoparticles (LNPs) are gaining traction in the field of nucleic acid delivery following the success of two mRNA vaccines against COVID-19. As one of the constituent lipids on LNP...
6.
Hu C, Napolitano J, Ma S, Hrovat F, Ragains M, Russell D, et al.
J Pharm Sci
. 2022 May;
111(8):2172-2179.
PMID: 35640732
Physical instability of aqueous drug solutions, such as precipitation upon storage, has so far been difficult to predict or model. Understanding the molecular basis of such phenomena can help mitigate...
7.
Nespi M, Kuhn R, Yen C, Lubach J, Leung D
AAPS PharmSciTech
. 2021 Dec;
23(1):28.
PMID: 34931259
Spray-drying dispersion (SDD) is a well-established manufacturing technique used to prepare amorphous solid dispersions (ASDs), allowing for poorly soluble drugs to have improved bioavailability. However, the process of spray-drying with...
8.
Levy E, Yu J, Estevez A, Mao J, Liu L, Torres E, et al.
AAPS J
. 2021 Oct;
23(6):111.
PMID: 34651233
Lipid nanoparticles have transformed the drug delivery field enhancing the therapeutic drug performance of small molecules and biologics with several approved drug products. However, in industry, these more complex drug...
9.
Pajer H, Asher A, Leung D, Barnett R, Joyner B, Quinsey C
Am J Crit Care
. 2021 Sep;
30(5):402-406.
PMID: 34467382
Pediatric traumatic brain injury (TBI) protocols vary widely among institutions, despite the existence of published guidelines. This study seeks to identify significant differences in management of pediatric TBI across several...
10.
Vachal P, Duffy J, Campeau L, Amin R, Mitra K, Murphy B, et al.
J Med Chem
. 2021 Aug;
64(18):13215-13258.
PMID: 34375108
Cholesteryl ester transfer protein (CETP) represents one of the key regulators of the homeostasis of lipid particles, including high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles. Epidemiological evidence correlates increased...