Dennis A Ausiello
Overview
Explore the profile of Dennis A Ausiello including associated specialties, affiliations and a list of published articles.
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23
Citations
641
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Recent Articles
1.
Bashyam A, Frangieh C, Raigani S, Sogo J, Bronson R, Uygun K, et al.
Nat Biomed Eng
. 2020 Dec;
5(3):240-251.
PMID: 33257853
Low-cost non-invasive diagnostic tools for staging the progression of non-alcoholic chronic liver failure from fatty liver disease to steatohepatitis are unavailable. Here, we describe the development and performance of a...
2.
Colucci L, Corapi K, Li M, Parada X, Allegretti A, Lin H, et al.
Sci Transl Med
. 2019 Jul;
11(502).
PMID: 31341060
Magnetic resonance imaging (MRI) is a powerful diagnostic tool, but its use is restricted to the scanner suite. Here, we demonstrate that a bedside nuclear magnetic resonance (NMR) sensor can...
3.
Marshansky V, Hosokawa H, Merkulova M, Bakulina A, Dip P, Thaker Y, et al.
Curr Top Membr
. 2019 Jun;
83:77-106.
PMID: 31196611
We have previously identified the interaction between mammalian V-ATPase a2-subunit isoform and cytohesin-2 (CTH2) and studied molecular details of binding between these proteins. In particular, we found that six peptides...
4.
Kamaly N, He J, Ausiello D, Farokhzad O
Nat Rev Nephrol
. 2016 Nov;
12(12):738-753.
PMID: 27795549
Treatment and management of kidney disease currently presents an enormous global burden, and the application of nanotechnology principles to renal disease therapy, although still at an early stage, has profound...
5.
Hosokawa H, Dip P, Merkulova M, Bakulina A, Zhuang Z, Khatri A, et al.
J Biol Chem
. 2013 Jan;
288(8):5896-913.
PMID: 23288846
Previously, we reported an acidification-dependent interaction of the endosomal vacuolar H(+)-ATPase (V-ATPase) with cytohesin-2, a GDP/GTP exchange factor (GEF), suggesting that it functions as a pH-sensing receptor. Here, we have...
6.
Bouley R, Nunes P, Andriopoulos Jr B, McLaughlin M, Webber M, Lin H, et al.
Am J Physiol Renal Physiol
. 2012 Dec;
304(5):F553-64.
PMID: 23235478
Vasopressin (VP) binds to the vasopressin type 2 receptor (V2R) to trigger physiological effects including body fluid homeostasis and blood pressure regulation. Signaling is terminated by receptor downregulation involving clathrin-mediated...
7.
Chen S, Webber M, Vilardaga J, Khatri A, Brown D, Ausiello D, et al.
Endocrinology
. 2011 Aug;
152(10):3893-904.
PMID: 21828182
The vasopressin receptor type 2 (V2R) is the major target of vasopressin (VP) in renal epithelial cells. Although it is known that VP induces V2R internalization, accumulation in the perinuclear...
8.
Merkulova M, Hurtado-Lorenzo A, Hosokawa H, Zhuang Z, Brown D, Ausiello D, et al.
Am J Physiol Cell Physiol
. 2011 Feb;
300(6):C1442-55.
PMID: 21307348
Previously, we demonstrated that the vacuolar-type H(+)-ATPase (V-ATPase) a2-subunit functions as an endosomal pH sensor that interacts with the ADP-ribosylation factor (Arf) guanine nucleotide exchange factor, ARNO. In the present...
9.
Brown D, Breton S, Ausiello D, Marshansky V
Traffic
. 2009 Jan;
10(3):275-84.
PMID: 19170982
The kidney regulates body fluid, ion and acid/base homeostasis through the interaction of a host of channels, transporters and pumps within specific tubule segments, specific cell types and specific plasma...
10.
Raychowdhury M, Ramos A, Zhang P, McLaughin M, Dai X, Chen X, et al.
Am J Physiol Renal Physiol
. 2008 Oct;
296(1):F87-97.
PMID: 18945824
The primary cilium of renal epithelial cells is a nonmotile sensory organelle, implicated in mechanosensory transduction signals. Recent studies from our laboratory indicate that renal epithelial primary cilia display abundant...