Denise Tischner
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Explore the profile of Denise Tischner including associated specialties, affiliations and a list of published articles.
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24
Citations
526
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Recent Articles
1.
Gurusamy M, Tischner D, Shao J, Klatt S, Zukunft S, Bonnavion R, et al.
Nat Commun
. 2021 Nov;
12(1):6798.
PMID: 34815397
G-protein-coupled receptors (GPCRs), especially chemokine receptors, play a central role in the regulation of T cell migration. Various GPCRs are upregulated in activated CD4 T cells, including P2Y10, a putative...
2.
Rocamora-Reverte L, Tuzlak S, von Raffay L, Tisch M, Fiegl H, Drach M, et al.
Front Immunol
. 2019 Apr;
10:472.
PMID: 30936873
Activation of the immune system increases systemic adrenal-derived glucocorticoid (GC) levels which downregulate the immune response as part of a negative feedback loop. While CD4 T cells are essential target...
3.
Tischner D, Grimm M, Kaur H, Staudenraus D, Carvalho J, Looso M, et al.
JCI Insight
. 2017 Aug;
2(15).
PMID: 28768912
GPCR expression was intensively studied in bulk cDNA of leukocyte populations, but limited data are available with respect to expression in individual cells. Here, we show a microfluidic-based single-cell GPCR...
4.
Wanke F, Moos S, Croxford A, Heinen A, Graf S, Kalt B, et al.
Cell Rep
. 2017 Feb;
18(5):1270-1284.
PMID: 28147280
Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7α,25-OHC,...
5.
Grimm M, Tischner D, Troidl K, Albarran Juarez J, Sivaraj K, Ferreiros Bouzas N, et al.
Arterioscler Thromb Vasc Biol
. 2015 Nov;
36(1):37-48.
PMID: 26603156
Objectives: Monocyte/macrophage recruitment and activation at vascular predilection sites plays a central role in the pathogenesis of atherosclerosis. Heterotrimeric G proteins of the G12/13 family have been implicated in the...
6.
Sivaraj K, Li R, Albarran-Juarez J, Wang S, Tischner D, Grimm M, et al.
Cardiovasc Res
. 2015 Aug;
108(1):171-80.
PMID: 26272756
Aims: VEGF A (VEGF-A) is a central regulator of pre- and postnatal vascular development. In vitro studies suggested that heterotrimeric G-proteins of the Gq/11 family contribute to VEGF receptor 2...
7.
Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, et al.
Glia
. 2015 Mar;
63(6):1083-99.
PMID: 25731696
The putative protein tyrosine kinase (PTK) inhibitor tyrphostin AG126 has proven beneficial in various models of inflammatory disease. Yet molecular targets and cellular mechanisms remained enigmatic. We demonstrate here that...
8.
Muller N, Fischer H, Tischner D, van den Brandt J, Reichardt H
J Immunol
. 2013 Mar;
190(8):4360-70.
PMID: 23475220
Glucocorticoids (GCs) repress lymphocyte function by controlling gene expression. In this study, we investigated Ag-specific effector T cells and provide evidence that GCs also modulate these cells' cytoskeletal architecture by...
9.
Labi V, Bertele D, Woess C, Tischner D, Bock F, Schwemmers S, et al.
EMBO Mol Med
. 2012 Nov;
5(1):122-36.
PMID: 23180554
Anti-apoptotic Bcl-2 family members are critical for the regulation of haematopoietic stem and progenitor cell (HSPC) survival. Little is known about the role of their pro-apoptotic antagonists, i.e. 'BH3-only' proteins,...
10.
Tischner D, Manzl C, Soratroi C, Villunger A, Krumschnabel G
Apoptosis
. 2012 Sep;
17(11):1197-1209.
PMID: 22971741
Necroptosis is a physiologically relevant mode of cell death with some well-described initiating events, but largely unknown executioners. Here we investigated necrostatin-1 (Nec-1) sensitive death elicited by different necroptosis stimuli...