Denis A Smirnov
Overview
Explore the profile of Denis A Smirnov including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
609
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Recent Articles
1.
Pal S, Patel J, He M, Foulk B, Kraft K, Smirnov D, et al.
Cancer
. 2017 Dec;
124(6):1216-1224.
PMID: 29266182
Background: Two androgen receptor (AR)-targeted therapies, enzalutamide and abiraterone acetate plus prednisone (abiraterone), have been approved for the treatment of metastatic castration-resistant prostate cancer (CRPC). Many patients respond to these...
2.
Babayan A, Alawi M, Gormley M, Muller V, Wikman H, McMullin R, et al.
Oncotarget
. 2017 Sep;
8(34):56066-56080.
PMID: 28915574
Background: Whole genome amplification (WGA) is required for single cell genotyping. Effectiveness of currently available WGA technologies in combination with next generation sequencing (NGS) and material preservation is still elusive....
3.
Dong Y, Skelley A, Merdek K, Sprott K, Jiang C, Pierceall W, et al.
J Mol Diagn
. 2012 Dec;
15(2):149-57.
PMID: 23266318
Circulating tumor cells (CTCs) are shed from cancerous tumors, enter the circulatory system, and migrate to distant organs to form metastases that ultimately lead to the death of most patients...
4.
Smirnov D, Brady L, Halasa K, Morley M, Solomon S, Cheung V
Genome Res
. 2011 Aug;
22(2):332-9.
PMID: 21844125
Radiation exposure through environmental, medical, and occupational settings is increasingly common. While radiation has harmful effects, it has utility in many applications such as radiotherapy for cancer. To increase the...
5.
Smirnov D, Morley M, Shin E, Spielman R, Cheung V
Nature
. 2009 Apr;
459(7246):587-91.
PMID: 19349959
Humans are exposed to radiation through the environment and in medical settings. To deal with radiation-induced damage, cells mount complex responses that rely on changes in gene expression. These gene...
6.
Smirnov D, Cheung V
Am J Hum Genet
. 2008 Aug;
83(2):243-53.
PMID: 18674748
The defining characteristic of recessive disorders is the absence of disease in heterozygous carriers of the mutant alleles. However, it has been recognized that recessive carriers may differ from noncarriers...
7.
Zweitzig D, Smirnov D, Connelly M, Terstappen L, OHara S, Moran E
Mol Cell Biochem
. 2007 Aug;
306(1-2):255-60.
PMID: 17694278
As an approach to understanding the factors that activate expression of tumor progression genes, the role of physiological stress in the activation of a panel of tumor cell markers was...
8.
Cohen S, Alpaugh R, Gross S, OHara S, Smirnov D, Terstappen L, et al.
Clin Colorectal Cancer
. 2006 Sep;
6(2):125-32.
PMID: 16945168
Purpose: Development of targeted therapeutic agents in colorectal cancer (CRC) is impeded by the lack of a noninvasive surrogate of drug effect. This pilot study evaluated the ability of immunomagnetic...
9.
Smirnov D, Foulk B, Doyle G, Connelly M, Terstappen L, OHara S
Cancer Res
. 2006 Mar;
66(6):2918-22.
PMID: 16540638
Increased numbers of endothelial cells are observed in peripheral blood of cancer patients. These circulating endothelial cells (CECs) may contribute to the formation of blood vessels in the tumor or...
10.
Smirnov D, Zweitzig D, Foulk B, Miller M, Doyle G, Pienta K, et al.
Cancer Res
. 2005 Jun;
65(12):4993-7.
PMID: 15958538
Metastases from primary tumors are responsible for most cancer deaths. It has been shown that circulating tumor cells (CTCs) can be detected in the peripheral blood of patients with a...