Physiological Stress Induces the Metastasis Marker AGR2 in Breast Cancer Cells

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2007 Aug 19

PMID 17694278

Citations 37

Authors

Daniel R Zweitzig

Denis A Smirnov

Mark C Connelly

Leon W M M Terstappen

S Mark OHara

Elizabeth Moran

Affiliations

Soon will be listed here.

Abstract

As an approach to understanding the factors that activate expression of tumor progression genes, the role of physiological stress in the activation of a panel of tumor cell markers was investigated. These studies identify the developmental gene product, anterior gradient 2 (AGR2) as a cancer cell marker specifically up-regulated in response to depletion of serum and oxygen. AGR2 has been identified as a tumor marker in primary and secondary cancer lesions, and as a marker for detection of circulating tumor cells (CTCs). Elevated levels of AGR2 are known to increase the metastatic potential of cancer cells, but conditions leading to increased expression of AGR2 are not well understood. The present results identify novel physiological parameters likely to contribute to AGR2 induction in situ.

Citing Articles

A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseases.

Esterhuizen M, Park C, Kim Y, Kim T, Yoon H, Andres F Front Mol Biosci. 2023; 10:1274221.

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AGR2 and FOXA1 as prognostic markers in ER-positive breast cancer.

Zhou M, Gan X, Ren Y, Chen Q, Yang Y, Weng Z BMC Cancer. 2023; 23(1):743.

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AGR2: a secreted protein worthy of attention in diagnosis and treatment of breast cancer.

Zhang K, Li Y, Kong X, Lei C, Yang H, Wang N Front Oncol. 2023; 13:1195885.

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Kosykh A, Tereshina M, Gurskaya N Int J Mol Sci. 2023; 24(9).

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