Demian F Obregon
Overview
Explore the profile of Demian F Obregon including associated specialties, affiliations and a list of published articles.
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12
Citations
344
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Recent Articles
1.
Deng J, Habib A, Obregon D, Barger S, Giunta B, Wang Y, et al.
J Neurochem
. 2015 Sep;
135(3):630-7.
PMID: 26342176
We recently found that sAPPα decreases amyloid-beta generation by directly associating with β-site amyloid precursor protein (APP)-converting enzyme 1 (BACE1), thereby modulating APP processing. Because inhibition of BACE1 decreases glycogen...
2.
Potential Autoepitope within the Extracellular Region of Contactin-Associated Protein-like 2 in Mice
Obregon D, Zhu Y, Bailey A, Portis S, Hou H, Zeng J, et al.
Br J Med Med Res
. 2014 Jan;
4(1):416-432.
PMID: 24466509
Aims: Implicated in autoimmune encephalitis, neuromyotonia and genetic forms of autism, here we report that contactin-associated protein-like 2 (CNTNAP2) contains a potential autoepitope within the extracellular region. Methodology: CNTNAP2 sequence-similar...
3.
Bailey A, Hou H, Song M, Obregon D, Portis S, Barger S, et al.
Glia
. 2013 Jul;
61(9):1556-69.
PMID: 23840007
Autistic individuals display impaired social interactions and language, and restricted, stereotyped behaviors. Elevated levels of secreted amyloid precursor protein-alpha (sAPPα), the product of α-secretase cleavage of APP, are found in...
4.
Bailey A, Hou H, Obregon D, Tian J, Zhu Y, Zou Q, et al.
FASEB J
. 2011 Nov;
26(3):1040-51.
PMID: 22085641
Abnormalities in T-lymphocyte populations and function are observed in autism. Soluble amyloid precursor protein α (sAPP-α) is elevated in some patients with autism and is known to be produced by...
5.
Obregon D, Velasco R, Wuerz T, Catalano M, Catalano G, Kahn D
J Psychiatr Pract
. 2011 Jul;
17(4):292-9.
PMID: 21775832
Catatonia is a movement disorder with various possible etiologies. The majority of cases are associated with an underlying mood or psychotic disorder, while others are caused by medical conditions. Currently,...
6.
Giunta B, Ehrhart J, Obregon D, Lam L, Le L, Jin J, et al.
Mol Brain
. 2011 Jun;
4(1):23.
PMID: 21649911
Up to 50% of long-term HIV infected patients, including those with systemically well-controlled infection, commonly experience memory problems and slowness, difficulties in concentration, planning, and multitasking. Deposition of Aβ plaques...
7.
Salemi J, Obregon D, Cobb A, Reed S, Sadic E, Jin J, et al.
Mol Neurodegener
. 2011 Jan;
6(1):3.
PMID: 21223591
Microglial dysfunction is associated with the pathogenesis and progression of a number of neurodegenerative disorders including HIV associated dementia (HAD). HIV promotion of an M1 antigen presenting cell (APC) -...
8.
Obregon D, Rezai-Zadeh K, Bai Y, Sun N, Hou H, Ehrhart J, et al.
J Biol Chem
. 2006 Apr;
281(24):16419-27.
PMID: 16624814
Recently, we have shown that green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) exerts a beneficial role on reducing brain Abeta levels, resulting in mitigation of cerebral amyloidosis in a mouse model of...
9.
Murthy S, Obregon D, Chattergoon N, Fonseca N, Mondal D, Dunne J, et al.
Metabolism
. 2005 May;
54(5):645-52.
PMID: 15877295
Homocysteine (Hcy) is a metabolite of the essential amino acid methionine. Hyperhomocysteinemia is associated with vascular disease, particularly carotid stenosis. Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma ,...
10.
Paris D, Townsend K, Quadros A, Humphrey J, Sun J, Brem S, et al.
Angiogenesis
. 2004 Aug;
7(1):75-85.
PMID: 15302999
Abeta peptides are naturally occurring peptides forming beta-sheet aggregates that constitute an integral component of senile plaques and vascular deposits in Alzheimer's disease. Since several peptides adopting a beta-sheet conformation...