Defne Bayik
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Explore the profile of Defne Bayik including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Kay K, Lee J, Hong E, Beilis J, Dayal S, Wesley E, et al.
J Clin Invest
. 2024 Nov;
135(2.
PMID: 39561012
The glioblastoma (GBM) microenvironment is enriched in immunosuppressive factors that potently interfere with the function of cytotoxic T lymphocytes. Cancer cells can directly affect the immune system, but the mechanisms...
2.
Seetharam D, Chandar J, Ramsoomair C, Desgraves J, Medina A, Hudson A, et al.
bioRxiv
. 2024 Oct;
PMID: 39464150
Viral mimicry refers to the activation of innate anti-viral immune responses due to the induction of endogenous retroelement (RE) expression. Viral mimicry has been previously described to augment anti-tumor immune...
3.
Pathak A, Palasalava S, Knott M, Colon B, Ciervo E, Zhou Y, et al.
bioRxiv
. 2024 Aug;
PMID: 39091833
Sex differences in immune responses impact cancer outcomes and treatment response, including in glioblastoma (GBM). However, host factors underlying sex specific immune-cancer interactions are poorly understood. Here, we identify the...
4.
5.
Karaman I, Pathak A, Bayik D, Watson D
Pathog Immun
. 2024 May;
9(1):56-90.
PMID: 38690563
There are a growing number of studies linking the composition of the human microbiome to disease states and treatment responses, especially in the context of cancer. This has raised significant...
6.
Kay K, Lee J, Hong E, Beilis J, Dayal S, Wesley E, et al.
bioRxiv
. 2023 Nov;
PMID: 38014234
The glioblastoma microenvironment is enriched in immunosuppressive factors that potently interfere with the function of cytotoxic T lymphocytes. Cancer cells can directly impact the immune system, but the mechanisms driving...
7.
Mitchell J, Colon B, Bayik D, Lathia J
Cell Rep Med
. 2023 Nov;
4(11):101293.
PMID: 37992680
In this issue, Pang and colleagues identify the protease legumain as a potential immunotherapy target in glioblastoma that drives tumor-associated macrophages in response to hypoxia.
8.
Teran Pumar O, Lathia J, Watson D, Bayik D
Trends Cancer
. 2023 Aug;
10(1):15-27.
PMID: 37625928
The Swiss cheese model is used to assess risks and explain accidents in a variety of industries. This model can be applied to dissect the homeostatic mechanisms whose cumulative dysregulation...
9.
Lee J, Nicosia M, Hong E, Silver D, Li C, Bayik D, et al.
Cancer Discov
. 2023 Jun;
13(9):2090-2105.
PMID: 37378557
Significance: Immunotherapies in patients with GBM have been unsuccessful due to a variety of factors, including the highly immunosuppressive tumor microenvironment in GBM. This study demonstrates that sex-biased T-cell behaviors...
10.
Alban T, Grabowski M, Otvos B, Bayik D, Wang W, Zalavadia A, et al.
JCI Insight
. 2023 May;
8(13).
PMID: 37252795
Intratumoral heterogeneity is a defining hallmark of glioblastoma, driving drug resistance and ultimately recurrence. Many somatic drivers of microenvironmental change have been shown to affect this heterogeneity and, ultimately, the...