Deepak Poria
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Explore the profile of Deepak Poria including associated specialties, affiliations and a list of published articles.
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10
Citations
78
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Recent Articles
1.
Volkov L, Ogawa Y, Somjee R, Vedder H, Powell H, Poria D, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(47):e2402121121.
PMID: 39531499
The role of transcription factors in photoreceptor gene regulation is fairly well understood, but knowledge of the cell-type-specific function of transcriptional cofactors remains incomplete. Here, we show that the transcriptional...
2.
Moakedi F, Aljammal R, Poria D, Saravanan T, Rhodes S, Reid C, et al.
Hum Mol Genet
. 2023 Jun;
32(17):2735-2750.
PMID: 37384398
Phosphodiesterase-6 (PDE6) is the key phototransduction effector enzyme residing in the outer segment (OS) of photoreceptors. Cone PDE6 is a tetrameric protein consisting of two inhibitory subunits (γ') and two...
3.
Poria D, Kolesnikov A, Lee T, Salom D, Palczewski K, Kefalov V
eNeuro
. 2023 Feb;
10(3).
PMID: 36823167
Rhodopsin is the critical receptor molecule which enables vertebrate rod photoreceptor cells to detect a single photon of light and initiate a cascade of molecular events leading to visual perception....
4.
Lankford C, Umino Y, Poria D, Kefalov V, Solessio E, Baker S
J Neurosci
. 2022 Apr;
42(21):4231-4249.
PMID: 35437278
Signal integration of converging neural circuits is poorly understood. One example is in the retina where the integration of rod and cone signaling is responsible for the large dynamic range...
5.
Poria D, Sun C, Santeford A, Kielar M, Apte R, Kisselev O, et al.
Sci Rep
. 2022 Feb;
12(1):2897.
PMID: 35190581
Calcium regulates the response sensitivity, kinetics and adaptation in photoreceptors. In striped bass cones, this calcium feedback includes direct modulation of the transduction cyclic nucleotide-gated (CNG) channels by the calcium-binding...
6.
Inamdar S, Lankford C, Poria D, Laird J, Solessio E, Kefalov V, et al.
Hum Mol Genet
. 2021 Oct;
31(7):1035-1050.
PMID: 34652420
Heteromeric Kv2.1/Kv8.2 channels are voltage-gated potassium channels localized to the photoreceptor inner segment. They carry IKx, which is largely responsible for setting the photoreceptor resting membrane potential. Mutations in Kv8.2...
7.
Bisbach C, Hutto R, Poria D, Cleghorn W, Abbas F, Vinberg F, et al.
Sci Rep
. 2020 Sep;
10(1):16041.
PMID: 32994451
Rods and cones use intracellular Ca to regulate many functions, including phototransduction and neurotransmission. The Mitochondrial Calcium Uniporter (MCU) complex is thought to be the primary pathway for Ca entry...
8.
Volkov L, Kim-Han J, Saunders L, Poria D, Hughes A, Kefalov V, et al.
Proc Natl Acad Sci U S A
. 2020 Jun;
117(26):15262-15269.
PMID: 32541022
Thyroid hormone (TH) signaling plays an important role in the regulation of long-wavelength vision in vertebrates. In the retina, () is required for expression of long-wavelength-sensitive opsin () in red...
9.
Krishnamoorthy V, Cherukuri P, Poria D, Goel M, Dagar S, Dhingra N
Front Cell Neurosci
. 2016 Mar;
10:38.
PMID: 26924962
Deafferentation results not only in sensory loss, but also in a variety of alterations in the postsynaptic circuitry. These alterations may have detrimental impact on potential treatment strategies. Progressive loss...
10.
Poria D, Dhingra N
J Neurophysiol
. 2014 Oct;
113(2):420-5.
PMID: 25355966
Retinal ganglion cells (RGCs) spike randomly in the dark and carry information about visual stimuli to the brain via specific spike patterns. However, following photoreceptor loss, both ON and OFF...