Deborah Wessels
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Explore the profile of Deborah Wessels including associated specialties, affiliations and a list of published articles.
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40
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943
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Recent Articles
1.
Wessels D, Lusche D, Voss E, Soll D
Methods Mol Biol
. 2021 Sep;
2364:299-318.
PMID: 34542859
Cancer cells from cell lines and tumor biopsy tissue undergo aggregation and aggregate coalescence when dispersed in a 3D Matrigel™ matrix. Coalescence is a dynamic process mediated by a subset...
2.
Conway T, Conway K, Boksa F, Pujol C, Wessels D, Soll D
mBio
. 2021 Sep;
12(5):e0232021.
PMID: 34488444
During induced differentiation, the process often involves a commitment event, after which induced cells, when returned to noninducing conditions, continue to differentiate. The commitment event is rarely identified. Candida albicans...
3.
Wessels D, Lusche D, Voss E, Kuhl S, Buchele E, Klemme M, et al.
PLoS One
. 2017 Mar;
12(3):e0173400.
PMID: 28264026
Using unique computer-assisted 3D reconstruction software, it was previously demonstrated that tumorigenic cell lines derived from breast tumors, when seeded in a 3D Matrigel model, grew as clonal aggregates which,...
4.
Kuhl S, Voss E, Scherer A, Lusche D, Wessels D, Soll D
Methods Mol Biol
. 2016 Jun;
1407:229-50.
PMID: 27271907
A 4D high-resolution computer-assisted reconstruction and motion analysis system has been developed and applied to the long-term (14-30 days) analysis of cancer cells migrating and aggregating within a 3D matrix....
5.
Ambrose J, Livitz M, Wessels D, Kuhl S, Lusche D, Scherer A, et al.
Am J Cancer Res
. 2016 Jan;
5(11):3485-504.
PMID: 26807328
Recently, we demonstrated that tumorigenic cell lines and fresh tumor cells seeded in a 3D Matrigel model, first grow as clonal islands (primary aggregates), then coalesce through the formation and...
6.
Scherer A, Kuhl S, Wessels D, Lusche D, Hanson B, Ambrose J, et al.
PLoS One
. 2015 Mar;
10(3):e0118628.
PMID: 25790299
We have developed a 4D computer-assisted reconstruction and motion analysis system, J3D-DIAS 4.1, and applied it to the reconstruction and motion analysis of tumorigenic cells in a 3D matrix. The...
7.
Lusche D, Wessels D, Richardson N, Russell K, Hanson B, Soll B, et al.
PLoS One
. 2014 Sep;
9(9):e108495.
PMID: 25247494
Mutations in the tumor suppressor gene PTEN are associated with a significant proportion of human cancers. Because the human genome also contains several homologs of PTEN, we considered the hypothesis...
8.
Wessels D, Lusche D, Scherer A, Kuhl S, Myre M, Soll D
Dev Biol
. 2014 Aug;
394(1):24-38.
PMID: 25149514
Huntington׳s disease is a neurodegenerative disorder, attributable to an expanded trinucleotide repeat in the coding region of the human HTT gene, which encodes the protein huntingtin. These mutations lead to...
9.
Wessels D, Lusche D, Steimle P, Scherer A, Kuhl S, Wood K, et al.
J Cell Sci
. 2012 Aug;
125(Pt 20):4934-44.
PMID: 22899719
Behavioral analyses of the deletion mutants of the four known myosin II heavy chain (Mhc) kinases of Dictyostelium discoideum revealed that all play a minor role in the efficiency of...
10.
Lusche D, Wessels D, Scherer A, Daniels K, Kuhl S, Soll D
J Cell Sci
. 2012 Mar;
125(Pt 7):1770-83.
PMID: 22375061
During aggregation of Dictyostelium discoideum, nondissipating, symmetrical, outwardly moving waves of cAMP direct cells towards aggregation centers. It has been assumed that the spatial and temporal characteristics of the front...