Mediated Coalescence: a Possible Mechanism for Tumor Cellular Heterogeneity

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2016 Jan 26

PMID 26807328

Citations 10

Authors

Joseph Ambrose

Michelle Livitz

Deborah Wessels

Spencer Kuhl

Daniel F Lusche

Amanda Scherer

Edward Voss

David R Soll

Affiliations

Soon will be listed here.

Abstract

Recently, we demonstrated that tumorigenic cell lines and fresh tumor cells seeded in a 3D Matrigel model, first grow as clonal islands (primary aggregates), then coalesce through the formation and contraction of cellular cables. Non-tumorigenic cell lines and cells from normal tissue form clonal islands, but do not form cables or coalesce. Here we show that as little as 5% tumorigenic cells will actively mediate coalescence between primary aggregates of majority non-tumorigenic or non-cancerous cells, by forming cellular cables between them. We suggest that this newly discovered, specialized characteristic of tumorigenic cells may explain, at least in part, why tumors contain primarily non-tumorigenic cells.

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