Deborah A Altomare
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Explore the profile of Deborah A Altomare including associated specialties, affiliations and a list of published articles.
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48
Citations
2354
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Recent Articles
1.
Oyer J, Croom-Perez T, Hasan M, Rivera-Huertas J, Gitto S, Mucha J, et al.
Front Immunol
. 2024 May;
15:1383281.
PMID: 38711506
NK cell therapeutics have gained significant attention as a potential cancer treatment. Towards therapeutic use, NK cells need to be activated and expanded to attain high potency and large quantities...
2.
Bernard J, Chinnaiyan V, Andl T, Le Bras G, Qureshi M, Altomare D, et al.
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36233047
Obesity is a known risk factor for the development of gastroesophageal reflux disease (GERD), Barrett's Esophagus (BE) and the progression to esophageal adenocarcinoma. The mechanisms by which obesity contributes to...
3.
Oyer J, Croom-Perez T, Dieffenthaller T, Robles-Carillo L, Gitto S, Altomare D, et al.
Front Immunol
. 2022 Apr;
13:861681.
PMID: 35464440
There is a great interest in developing natural killer (NK) cells as adoptive cancer immunotherapy. For off-the-shelf approaches and to conduct multicenter clinical trials, cryopreserved NK cells are the preferred...
4.
Gitto S, Nakkina S, Beardsley J, Parikh J, Altomare D
Methods Cell Biol
. 2022 Apr;
168:139-159.
PMID: 35366980
Chronic inflammation is known to be associated with pancreatic cancer, however a complete picture regarding how these pathologies intersect is still being characterized. In vivo model systems are critical for...
5.
Arnoletti J, Reza J, Rosales A, Monreal A, Fanaian N, Whisner S, et al.
PLoS One
. 2022 Mar;
17(3):e0265725.
PMID: 35316296
The portal venous circulation provides a conduit for pancreatic ductal adenocarcinoma (PDAC) tumor cells to the liver parenchyma sinusoids, a frequent site of metastasis. Turbulent flow in the portal circulation...
6.
Nakkina S, Gitto S, Beardsley J, Pandey V, Rohr M, Parikh J, et al.
Int J Mol Sci
. 2021 Dec;
22(24).
PMID: 34947972
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor five-year survival rate of less than 10%. Immune suppression along with chemoresistance are obstacles for PDAC therapeutic treatment. Innate immune cells, such...
7.
Nakkina S, Gitto S, Pandey V, Parikh J, Geerts D, Maurer H, et al.
Cancers (Basel)
. 2021 Dec;
13(24).
PMID: 34945011
Pancreatic cancer is the fourth leading cause of cancer death. Existing therapies only moderately improve pancreatic ductal adenocarcinoma (PDAC) patient prognosis. The present study investigates the importance of the polyamine...
8.
Dobrovolskaite A, Madan M, Pandey V, Altomare D, Phanstiel 4th O
Int J Biochem Cell Biol
. 2021 Jul;
138:106038.
PMID: 34252566
The native polyamines putrescine, spermidine, and spermine are essential for cell development and proliferation. Polyamine levels are often increased in cancer tissues and polyamine depletion is a validated anticancer strategy....
9.
Rohr M, Aljabban J, Rudeski-Rohr T, Lessans S, Nakkina S, Hadley D, et al.
Clin Transl Gastroenterol
. 2021 Jan;
12(1):e00295.
PMID: 33492921
Introduction: Bile acids (BAs) arising from duodenogastric reflux are known to facilitate gastric cancer (GC) development. Although BAs traditionally contribute to carcinogenesis through direct cellular cytotoxicity, increasing evidence implicates nuclear...
10.
Gitto S, Beardsley J, Nakkina S, Oyer J, Cline K, Litherland S, et al.
Cell Commun Signal
. 2020 Jun;
18(1):95.
PMID: 32552827
Background: While inflammation is associated with pancreatic cancer, the underlying mechanisms leading to cancer initiation are still being delineated. Eosinophils may promote or inhibit tumor growth, although the specific role...