Andres J Klein-Szanto
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Explore the profile of Andres J Klein-Szanto including associated specialties, affiliations and a list of published articles.
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109
Citations
4684
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Recent Articles
1.
Strandberg J, Louie A, Lee S, Hahn M, Srinivasan P, George A, et al.
J Clin Invest
. 2025 Jan;
135(5).
PMID: 39808500
Radiotherapy can be limited by pneumonitis, which is impacted by innate immunity, including pathways regulated by TRAIL death receptor DR5. We investigated whether DR5 agonists could rescue mice from toxic...
2.
Shin A, Sugiura K, Kariuki S, Cohen D, Flashner S, Klein-Szanto A, et al.
J Clin Invest
. 2025 Jan;
PMID: 39808497
Colorectal cancer (CRC) remains a leading cause of cancer death due to metastatic spread. LIN28B is overexpressed in 30% of CRCs and promotes metastasis, yet its mechanisms remain unclear. In...
3.
Shimonosono M, Morimoto M, Hirose W, Tomita Y, Matsuura N, Flashner S, et al.
Biomolecules
. 2024 Sep;
14(9).
PMID: 39334892
Esophageal organoids from a variety of pathologies including cancer are grown in Advanced Dulbecco's Modified Eagle Medium-Nutrient Mixture F12 (hereafter ADF). However, the currently available ADF-based formulations are suboptimal for...
4.
Shimonosono M, Morimoto M, Hirose W, Tomita Y, Matsuura N, Flashner S, et al.
bioRxiv
. 2024 Jun;
PMID: 38826379
Background: Esophageal organoids from a variety of pathologies including cancer are grown in Advanced Dulbecco's Modified Eagle Medium-Nutrient Mixture F12 (hereafter ADF). However, the currently available ADF-based formulations are suboptimal...
5.
Vendramini-Costa D, Francescone R, Franco-Barraza J, Luong T, Graves M, de Aquino A, et al.
bioRxiv
. 2024 May;
PMID: 38798370
Statement Of Significance: Here we uncovered the pro-tumor roles of the synaptic protein NGL-1 in the tumor microenvironment of pancreatic cancer, defining a new target that simultaneously modulates tumor cell,...
6.
Kadariya Y, Sementino E, Ruan M, Cheung M, Hadikhani P, Osmanbeyoglu H, et al.
Cancer Res Commun
. 2024 Apr;
4(4):1004-1015.
PMID: 38592450
Significance: We show that germline Bap1-mutant mice have enhanced susceptibility to MM upon minimal exposure to chrysotile asbestos, not only amphibole fibers. Chrysotile induced a more profound immune tumor response...
7.
Klochkova A, Karami A, Fuller A, Parham L, Panchani S, Natarajan S, et al.
Cell Mol Gastroenterol Hepatol
. 2024 Mar;
18(1):15-40.
PMID: 38452871
Background & Aims: Autophagy plays roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelial homeostasis. Methods: We generated tamoxifen-inducible,...
8.
Masuda M, Pyon G, Luo H, LeSuer W, Putikova A, Dao A, et al.
J Allergy Clin Immunol
. 2024 Feb;
153(5):1355-1368.
PMID: 38310974
Background: Eosinophilic esophagitis (EoE) is an increasingly common inflammatory condition of the esophagus; however, the underlying immunologic mechanisms remain poorly understood. The epithelium-derived cytokine IL-33 is associated with type 2...
9.
Flashner S, Shimonosono M, Tomita Y, Matsuura N, Ohashi S, Muto M, et al.
Carcinogenesis
. 2023 Nov;
45(1-2):95-106.
PMID: 37978873
The alcohol metabolite acetaldehyde is a potent human carcinogen linked to esophageal squamous cell carcinoma (ESCC) initiation and development. Aldehyde dehydrogenase 2 (ALDH2) is the primary enzyme that detoxifies acetaldehyde...
10.
Klochkova A, Karami A, Fuller A, Parham L, Panchani S, Natarajan S, et al.
bioRxiv
. 2023 Oct;
PMID: 37781581
Background & Aims: Autophagy has been demonstrated to play roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelium under...