Debkumar Pain
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Explore the profile of Debkumar Pain including associated specialties, affiliations and a list of published articles.
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40
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1492
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Recent Articles
1.
Mitochondrial glutaredoxin Grx5 functions as a central hub for cellular iron-sulfur cluster assembly
Pandey A, Pain J, Singh P, Dancis A, Pain D
J Biol Chem
. 2025 Mar;
:108391.
PMID: 40074084
Iron-sulfur (FeS) protein biogenesis in eukaryotes is mediated by two different machineries - one in the mitochondria and another in the cytoplasm. Glutaredoxin 5 (Grx5) is a component of the...
2.
Pandey A, Yoon H, Pain J, Dancis A, Pain D
Mitochondrion
. 2024 Sep;
79:101955.
PMID: 39251117
Mitochondria perform vital biosynthetic processes, including fatty acid synthesis and iron-sulfur (FeS) cluster biogenesis. In Saccharomyces cerevisiae mitochondria, the acyl carrier protein Acp1 participates in type II fatty acid synthesis,...
3.
Dancis A, Pandey A, Pain D
Biochim Biophys Acta Mol Cell Res
. 2024 Apr;
1871(5):119733.
PMID: 38641180
Iron‑sulfur (FeS) clusters are cofactors of numerous proteins involved in essential cellular functions including respiration, protein translation, DNA synthesis and repair, ribosome maturation, anti-viral responses, and isopropylmalate isomerase activity. Novel...
4.
Lail N, Pandey A, Venkatesh S, Noland R, Swanson G, Pain D, et al.
Neurology
. 2023 Jul;
101(15):e1567-e1571.
PMID: 37460232
Pathogenic biallelic variants in , which encodes the enzyme mitochondrial aconitase, are associated with the very rare diagnosis of -related infantile cerebellar retinal degeneration (OMIM 614559). We describe the diagnostic...
5.
Pandey A, Pain J, J B, Dancis A, Pain D
Mitochondrion
. 2023 Feb;
69:104-115.
PMID: 36773733
Iron-sulfur (Fe-S) cluster assembly in mitochondria and cytoplasm is essential for cell viability. In the yeast S. cerevisiae, Leu1 [4Fe-4S] is the cytoplasmic isopropylmalate isomerase involved in leucine biosynthesis. Using...
6.
Lewis B, Campbell C, Rodrigues A, Thompson L, Pandey A, Gallagher S, et al.
J Biol Inorg Chem
. 2022 Oct;
27(8):759-773.
PMID: 36309885
Mitochondrial [2Fe-2S] cluster biosynthesis is driven by the coordinated activities of the Iron-Sulfur Cluster (ISC) pathway protein machinery. Within the ISC machinery, the protein that provides a structural scaffold on...
7.
Pandey A, Pain J, Dancis A, Pain D
J Biol Chem
. 2019 May;
294(24):9489-9502.
PMID: 31040179
Iron-sulfur clusters are essential cofactors of proteins. In eukaryotes, iron-sulfur cluster biogenesis requires a mitochondrial iron-sulfur cluster machinery (ISC) and a cytoplasmic iron-sulfur protein assembly machinery (CIA). Here we used...
8.
Knight S, Yoon H, Pandey A, Pain J, Pain D, Dancis A
Mitochondrion
. 2019 Jan;
47:256-265.
PMID: 30660752
Rim2 is an unusual mitochondrial carrier protein capable of transporting both iron and pyrimidine nucleotides. Here we characterize two point mutations generated in the predicted substrate-binding site, finding that they...
9.
Pandey A, Pain J, Dziuba N, Pandey A, Dancis A, Lindahl P, et al.
Cell Chem Biol
. 2018 May;
25(6):738-748.e3.
PMID: 29706592
In eukaryotes, mitochondria have been hypothesized to generate sulfur species required for tRNA thiolation in the cytosol, although no direct evidence thus far exists. Here we have detected these sulfur...
10.
Rocha A, Knight S, Pandey A, Yoon H, Pain J, Pain D, et al.
Data Brief
. 2017 Nov;
15:775-799.
PMID: 29159215
Fe-S clusters are cofactors that participate in diverse and essential biological processes. Mitochondria contain a complete machinery for Fe-S cluster assembly. Cysteine desulfurase (Nfs1) is required generation of a form...