Debbie Higgins
Overview
Explore the profile of Debbie Higgins including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
100
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0
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Recent Articles
1.
Andrews C, Huh M, Patton K, Higgins D, Van Nest G, Ott G, et al.
Mol Pharm
. 2012 Mar;
9(5):1118-25.
PMID: 22376145
Immunostimulatory sequences (ISS) are short DNA sequences containing unmethylated CpG dimers that have multiple effects on the host immune system, including the ability to stimulate antigen-specific cytotoxic T lymphocytes (CTLs)...
2.
Higgins D, Marshall J, Traquina P, Van Nest G, Livingston B
Expert Rev Vaccines
. 2007 Oct;
6(5):747-59.
PMID: 17931155
Immunostimulatory DNA containing unmethylated CpG motifs is recognized by Toll-like receptor 9, resulting in the activation of innate immune responses that subsequently amplify the adaptive-immune response. Advances in the characterization...
3.
Livingston B, Higgins D, Van Nest G
BioDrugs
. 2006 Dec;
20(6):335-40.
PMID: 17176120
Approved influenza vaccines based on the induction of antibodies to hemagglutinin are strain specific and cumbersome to manufacture. Several alternative vaccine strategies based on the induction of humoral responses against...
4.
Marshall J, Fearon K, Higgins D, Hessel E, Kanzler H, Abbate C, et al.
DNA Cell Biol
. 2005 Feb;
24(2):63-72.
PMID: 15699627
CpG-C are a novel class of CpG motif-containing immunostimulatory sequences (ISS) that includes both a 5'-TCG element and a CpG-containing palindrome. CpG-C drive all known ISS activities and, in particular,...
5.
Marshall J, Higgins D, Abbate C, Yee P, Teshima G, Ott G, et al.
Cell Immunol
. 2004 Oct;
229(2):93-105.
PMID: 15474524
The immunostimulatory effects of bacterial DNA on mammalian cells have been localized to unmethylated CpG motifs, and synthetic CpG-containing oligodeoxynucleotides that mimic these effects are known as immunostimulatory sequences (ISS)....
6.
Pyles R, Higgins D, Chalk C, Zalar A, Eiden J, Brown C, et al.
J Virol
. 2002 Oct;
76(22):11387-96.
PMID: 12388699
Synthetic oligonucleotides containing CpG motifs in specific sequence contexts have been shown to induce potent immune responses. We have evaluated mucosal administration of two immunostimulatory sequence (ISS)-containing phosphorothioate-stabilized oligonucleotides for...