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Richard B Pyles

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Citations 1492
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Recent Articles
1.
Bourne N, Keith C, Miller A, Pyles R, Milligan G
Virology . 2024 Nov; 588:109907. PMID: 39492229
CD4 and CD8 tissue resident memory cells (TRM) express many shared anti-viral activities upon re-exposure to virus. CD4 T cells were depleted from HSV-immune guinea pigs to identify CD4-dependent functions...
2.
Wright T, Sheffield-Moore M, Pyles R, Randolph K, McGovern K, Danesi C, et al.
Clin Transl Sci . 2024 Jun; 17(6):e13826. PMID: 38894576
Following SARS-CoV-2 infection, some patients develop lingering neurologic symptoms of post-acute sequelae of COVID-19 (PASC) that commonly include fatigue and "brain fog." PASC symptoms are also linked with reduced growth...
3.
Goldenberg J, Wright T, Batson R, Wexler R, McGovern K, Venugopal N, et al.
BMJ Open . 2024 Jun; 14(6):e077873. PMID: 38890133
Introduction: Cognitive impairment is reported in a variety of clinical conditions including Alzheimer's disease, Parkinson's and 'long-COVID'. Interestingly, many of these clinical conditions are also associated with microbial dysbiosis. This...
4.
Pyles R, Miller A, Urban R, Sheffield-Moore M, Wright T, Maxwell C, et al.
Front Mol Neurosci . 2024 Mar; 17:1341808. PMID: 38544523
Introduction: Patients who suffer a traumatic brain injury (TBI) often experience chronic and sometimes debilitating sequelae. Recent reports have illustrated both acute and long-term dysbiosis of the gastrointestinal microbiome with...
5.
Wright T, Elliott T, Randolph K, Pyles R, Masel B, Urban R, et al.
PLoS One . 2024 Mar; 19(3):e0300910. PMID: 38517903
Background: Following traumatic brain injury (TBI) some patients develop lingering comorbid symptoms of fatigue and cognitive impairment. The mild cognitive impairment self-reported by patients is often not detected with neurocognitive...
6.
Elliott T, Hsiao Y, Randolph K, Urban R, Sheffield-Moore M, Pyles R, et al.
PLoS One . 2023 Dec; 18(12):e0295593. PMID: 38079429
Debilitating symptoms of fatigue and accompanying "brain fog" are observed among patients with various chronic health conditions. Unfortunately, an efficient and psychometrically sound instrument to assess these co-occurring symptoms is...
7.
Zahra A, Menon R, Cosi Bento G, Selim J, Taylor B, Vincent K, et al.
Am J Reprod Immunol . 2023 Nov; 90(6):e13797. PMID: 38009054
The vaginal microbiome includes diverse microbiota dominated by Lactobacillus [L.] spp. that protect against infections, modulate inflammation, and regulate vaginal homeostasis. Because it is challenging to incorporate vaginal microbiota into...
8.
Armstrong P, Venugopal N, Wright T, Randolph K, Batson R, Yuen K, et al.
Best Pract Res Clin Endocrinol Metab . 2023 Nov; 37(6):101841. PMID: 38000973
The gut microbiome has been implicated in a variety of neuropathologies with recent data suggesting direct effects of the microbiome on host metabolism, hormonal regulation, and pathophysiology. Studies have shown...
9.
Venugopal N, Armstrong P, Wright T, Randolph K, Batson R, Yuen K, et al.
Best Pract Res Clin Endocrinol Metab . 2023 Nov; 37(6):101842. PMID: 37996257
The SARS-CoV-2 pandemic created a multitude of medical crossroads requiring real time adaptations of best practice covering preventative and interventional aspects of care. Among the many discoveries borne from efforts...
10.
Wright T, Pyles R, Sheffield-Moore M, Deer R, Randolph K, McGovern K, et al.
Mol Cell Endocrinol . 2023 Oct; 579:112071. PMID: 37816478
Objective: To determine if patients that develop lingering neurologic symptoms of fatigue and "brain fog" after initial recovery from coronavirus disease 2019 (COVID-19) have persistent low growth hormone (GH) secretion...