De-Xin Kong
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Explore the profile of De-Xin Kong including associated specialties, affiliations and a list of published articles.
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56
Citations
399
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Recent Articles
1.
Liu Y, Cai M, Zhao Y, Hu Z, Wu P, Kong D
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39519027
The identification of natural products (NPs) has played a pivotal role in drug discovery and shaped the evolution of synthetic compounds (SCs). However, the extent to which NPs have historically...
2.
Li W, Chen Y, Yang R, Hu Z, Wei S, Hu S, et al.
Database (Oxford)
. 2024 May;
2024.
PMID: 38776380
Natural products play a pivotal role in drug discovery, and the richness of natural products, albeit significantly influenced by various environmental factors, is predominantly determined by intrinsic genetics of a...
3.
Wen S, Zhao Y, Qi X, Cai M, Huang K, Liu H, et al.
Comput Struct Biotechnol J
. 2024 Jan;
23:537-548.
PMID: 38235361
CRISPR-Cas9 systems constitute bacterial adaptive immune systems that protect against phage infections. Bacteriophages encode anti-CRISPR proteins (Acrs) that mitigate the bacterial immune response. However, the structural basis for their inhibitory...
4.
Wang Y, Peng Y, Long R, Shi P, Zhang Y, Kong D, et al.
Comput Struct Biotechnol J
. 2023 Sep;
21:4159-4171.
PMID: 37675287
Siglecs are important lectins found in different types of immune cells and function as regulatory molecules by recognizing self-associated glycans and converting extracellular interactions into signals for inhibiting immune cell...
5.
Zhang M, Zhao X, Li W, Wang X, Niu M, Zhang H, et al.
Chin Med
. 2023 Aug;
18(1):102.
PMID: 37592331
Ethnopharmacological Relevance: Psoralea corylifolia Linn. (BGZ) is a commonly used traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency syndrome (Yang) with good curative effect and security. However, BGZ...
6.
Huang K, Liu Y, Wen S, Zhao Y, Ding H, Liu H, et al.
Molecules
. 2023 Jun;
28(12).
PMID: 37375166
The intricate complex system of the differentiation 47 (CD47) and the signal-regulatory protein alpha (SIRPα) cluster is a crucial target for cancer immunotherapy. Although the conformational state of the CD47-SIRPα...
7.
Chen Y, Liu Y, Chen N, Jin Y, Yang R, Yao H, et al.
Nat Prod Rep
. 2023 Apr;
40(9):1464-1478.
PMID: 37070562
Covering: up to 202216.19% of reported natural products (NPs) in the Dictionary of Natural Products (DNP) are glycosides. As one of the most important NPs' structural modifications, glycosylation can change...
8.
Zhang M, Li W, Wang X, Wu Y, Chen X, Zhang H, et al.
Front Cell Infect Microbiol
. 2023 Jan;
12:1095053.
PMID: 36710971
Background: Increasing evidence suggests that gut dysbiosis can directly or indirectly affect the immune system through the brain-gut axis and play a role in the occurrence and development of Multiple...
9.
Wang D, Wu Z, Shen C, Bao L, Luo H, Wang Z, et al.
Brief Bioinform
. 2022 Dec;
24(1).
PMID: 36573494
Machine learning including modern deep learning models has been extensively used in drug design and screening. However, reliable prediction of molecular properties is still challenging when exploring out-of-domain regimes, even...
10.
Li L, Lyu X, Qiu Y, Kong D
Zhongguo Ying Yong Sheng Li Xue Za Zhi
. 2022 Sep;
38(3):273-278.
PMID: 36062799
By means of network pharmacology, potential targets and molecular pathways of QiZhenYuanDan in the treatment of atherosclerosis (AS) were studied. TCMSP database was used to obtain the main active components...