Dayong Zhai
Overview
Explore the profile of Dayong Zhai including associated specialties, affiliations and a list of published articles.
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48
Citations
2719
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0
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Recent Articles
1.
Murray B, Rogers E, Zhai D, Deng W, Chen X, Sprengeler P, et al.
Mol Cancer Ther
. 2021 Oct;
20(12):2446-2456.
PMID: 34625502
chromosomal rearrangements yield oncogenic TRK fusion proteins that are sensitive to TRK inhibitors (larotrectinib and entrectinib) but often mutate, limiting the durability of response for patients. Next-generation inhibitors with compact...
2.
Murray B, Zhai D, Deng W, Zhang X, Ung J, Nguyen V, et al.
Mol Cancer Ther
. 2021 Jun;
20(9):1499-1507.
PMID: 34158340
Since 2011, with the approval of crizotinib and subsequent approval of four additional targeted therapies, anaplastic lymphoma kinase (ALK) inhibitors have become important treatments for a subset of patients with...
3.
Drilon A, Ou S, Cho B, Kim D, Lee J, Lin J, et al.
Cancer Discov
. 2018 Aug;
8(10):1227-1236.
PMID: 30093503
The use of tyrosine kinase inhibitors (TKI) with activity against ALK, ROS1, or TRKA-C can result in significant clinical benefit in patients with diverse tumors harboring , or rearrangements; however,...
4.
Lee H, Rotolo J, Mesicek J, Penate-Medina T, Rimner A, Liao W, et al.
PLoS One
. 2015 Dec;
10(12):e0146210.
PMID: 26716446
No abstract available.
5.
Hassig C, Zeng F, Kung P, Kiankarimi M, Kim S, Diaz P, et al.
J Biomol Screen
. 2014 May;
19(8):1201-11.
PMID: 24870016
Antiapoptotic Bcl-2 family proteins are validated cancer targets composed of six related proteins. From a drug discovery perspective, these are challenging targets that exert their cellular functions through protein-protein interactions...
6.
Goff D, Court Recart A, Sadarangani A, Chun H, Barrett C, Krajewska M, et al.
Cell Stem Cell
. 2013 Jan;
12(3):316-28.
PMID: 23333150
Leukemia stem cells (LSCs) play a pivotal role in the resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitors (TKIs) and its progression to blast crisis (BC), in part,...
7.
Wei J, Stebbins J, Kitada S, Dash R, Zhai D, Placzek W, et al.
Front Oncol
. 2012 Jun;
1:28.
PMID: 22655238
Our focus in the past several years has been on the identification of novel and effective pan-Bcl-2 antagonists. We have recently reported a series of Apogossypolone (ApoG2) derivatives, resulting in...
8.
Zhai D, Godoi P, Sergienko E, Dahl R, Chan X, Brown B, et al.
J Biomol Screen
. 2011 Dec;
17(3):350-60.
PMID: 22156224
Overexpression of the anti-apoptotic Bcl-2 family proteins occurs commonly in human cancers. Bfl-1 is highly expressed in some types of malignant cells, contributing significantly to tumor cell survival and chemoresistance....
9.
Askari N, Correa R, Zhai D, Reed J
J Biotechnol
. 2011 Nov;
157(1):75-81.
PMID: 22062585
NOD1 (NLRC1) is a member of the NLR family of innate immunity proteins, which are important cellular sensors of various pathogens. Deregulated NOD1 signaling is involved in various autoimmune, inflammatory,...
10.
Correa R, Khan P, Askari N, Zhai D, Gerlic M, Brown B, et al.
Chem Biol
. 2011 Aug;
18(7):825-32.
PMID: 21802003
NLR family proteins play important roles in innate immune response. NOD1 (NLRC1) activates various signaling pathways including NF-κB in response to bacterial ligands. Hereditary polymorphisms in the NOD1 gene are...