Davide Mercadante
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Explore the profile of Davide Mercadante including associated specialties, affiliations and a list of published articles.
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38
Citations
710
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Recent Articles
1.
Swain B, Sarkis P, Ung V, Rousseau S, Fernandez L, Meltonyan A, et al.
Nat Commun
. 2024 Oct;
15(1):8766.
PMID: 39384813
Eukaryotic translation initiation factor eIF4B is required for efficient cap-dependent translation, it is overexpressed in cancer cells, and may influence stress granule formation. Due to the high degree of intrinsic...
2.
McIvor J, Larsen D, Mercadante D
J Chem Inf Model
. 2024 Jul;
64(15):6041-6052.
PMID: 39074869
Structural disorder in proteins is central to cellular signaling, where conformational plasticity equips molecules to promiscuously interact with different partners. By engaging with multiple binding partners via the rearrangement of...
3.
Bjarnason S, McIvor J, Prestel A, Demeny K, Bullerjahn J, Kragelund B, et al.
Nat Commun
. 2024 Feb;
15(1):1445.
PMID: 38365983
More than 1600 human transcription factors orchestrate the transcriptional machinery to control gene expression and cell fate. Their function is conveyed through intrinsically disordered regions (IDRs) containing activation or repression...
4.
Hocq L, Habrylo O, Senechal F, Voxeur A, Pau-Roblot C, Safran J, et al.
Plant Cell Physiol
. 2024 Jan;
65(2):301-318.
PMID: 38190549
Pectin methylesterases (PMEs) modify homogalacturonan's chemistry and play a key role in regulating primary cell wall mechanical properties. Here, we report on Arabidopsis AtPME2, which we found to be highly...
5.
Safran J, Tabi W, Ung V, Lemaire A, Habrylo O, Bouckaert J, et al.
Plant Cell
. 2023 May;
35(8):3073-3091.
PMID: 37202370
Polygalacturonases (PGs) fine-tune pectins to modulate cell wall chemistry and mechanics, impacting plant development. The large number of PGs encoded in plant genomes leads to questions on the diversity and...
6.
Safran J, Ung V, Bouckaert J, Habrylo O, Molinie R, Fontaine J, et al.
Int J Biol Macromol
. 2023 Jan;
231:123137.
PMID: 36639075
Pectins, complex polysaccharides and major components of the plant primary cell wall, can be degraded by pectate lyases (PLs). PLs cleave glycosidic bonds of homogalacturonans (HG), the main pectic domain,...
7.
Mckerchar H, Lento C, Bennie R, Crowther J, Dolamore F, Dyer J, et al.
Food Chem
. 2022 Dec;
408:135229.
PMID: 36563618
The properties of milk proteins differ between mammalian species. β-Lactoglobulin (βlg) proteins from caprine and bovine milk are sequentially and structurally highly similar, yet their physicochemical properties differ, particularly in...
8.
Buholzer K, McIvor J, Zosel F, Teppich C, Nettels D, Mercadante D, et al.
J Chem Phys
. 2022 Dec;
157(23):235102.
PMID: 36550025
Intrinsically disordered proteins (IDPs) play key roles in cellular regulation, including signal transduction, transcription, and cell-cycle control. Accordingly, IDPs can commonly interact with numerous different target proteins, and their interaction...
9.
Tian P, Lemaire A, Senechal F, Habrylo O, Antonietti V, Sonnet P, et al.
Angew Chem Int Ed Engl
. 2022 Oct;
61(50):e202202711.
PMID: 36259321
Efficient design of functional proteins with higher thermal stability remains challenging especially for highly diverse sequence variants. Considering the evolutionary pressure on protein folds, sequence design optimizing evolutionary fitness could...
10.
McIvor J, Larsen D, Mercadante D
J Phys Chem B
. 2022 Sep;
126(40):7833-7846.
PMID: 36125334
We simulated the dynamics of a set of peptides characterized by ensembles rich in PPII-helical content, to assess the ability of the most recent Kirkwood-Buff force field (KBFF20) to sample...