Edward A Lemke
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Explore the profile of Edward A Lemke including associated specialties, affiliations and a list of published articles.
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114
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5673
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Recent Articles
1.
Brzezinski M, Argudo P, Scheidt T, Yu M, Hosseini E, Kaltbeitzel A, et al.
Biomacromolecules
. 2024 Dec;
PMID: 39648588
Macromolecular crowding agents, such as poly(ethylene glycol) (PEG), are often used to mimic cellular cytoplasm in protein assembly studies. Despite the perception that crowding agents have an inert nature, we...
2.
Yu M, Gruzinov A, Ruan H, Scheidt T, Chowdhury A, Giofre S, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(50):e2415220121.
PMID: 39642200
Intrinsically disordered proteins (IDPs) adopt ensembles of rapidly fluctuating heterogeneous conformations, influencing their binding capabilities and supramolecular transitions. The primary conformational descriptors for understanding IDP ensembles-the radius of gyration (),...
3.
Schartel L, Jann C, Wierczeiko A, Butto T, Mundnich S, Marchand V, et al.
Nat Commun
. 2024 Oct;
15(1):9177.
PMID: 39448590
RNA modifications play a pivotal role in the regulation of RNA chemistry within cells. Several technologies have been developed with the goal of using RNA modifications to regulate cellular biochemistry...
4.
Bhattacharjee R, Lemke E
J Mol Biol
. 2024 Oct;
436(21):168807.
PMID: 39357814
Following decades of innovation and perfecting, genetic code expansion has become a powerful tool for in vivo protein modification. Some of the major hurdles that had to be overcome include...
5.
Jann C, Giofre S, Bhattacharjee R, Lemke E
Chem Rev
. 2024 Aug;
124(18):10281-10362.
PMID: 39120726
Over 500 natural and synthetic amino acids have been genetically encoded in the last two decades. Incorporating these noncanonical amino acids into proteins enables many powerful applications, ranging from basic...
6.
Sushkin M, Jung M, Lemke E
J Mol Biol
. 2024 Aug;
436(21):168728.
PMID: 39089364
Site-specific incorporation of noncanonical amino acids (ncAAs) can be realized by genetic code expansion (GCE) technology. Different orthogonal tRNA synthetase/tRNA (RS/tRNA) pairs have been developed to introduce a ncAA at...
7.
Lemke E, Babu M, Kriwacki R, Mittag T, Pappu R, Wright P, et al.
Mol Cell
. 2024 Apr;
84(7):1188-1190.
PMID: 38579677
In his commentary in this issue of Molecular Cell, Struhl reasons that the term "intrinsically disordered regions" represents a vague and confusing concept for protein function. However, the term "intrinsically...
8.
Ao Y, Grover J, Gifford L, Han Y, Zhong G, Katte R, et al.
Cell Chem Biol
. 2024 Jan;
31(3):487-501.e7.
PMID: 38232732
Structural dynamics of human immunodeficiency virus 1 (HIV-1) envelope (Env) glycoprotein mediate cell entry and facilitate immune evasion. Single-molecule FRET using peptides for Env labeling revealed structural dynamics of Env,...
9.
Sushkin M, Koehler C, Lemke E
Nat Commun
. 2023 Oct;
14(1):6931.
PMID: 37903771
Genetic code expansion (GCE) reprograms the translational machinery to site-specifically incorporate noncanonical amino acids (ncAAs) into a selected protein. The efficiency of GCE in mammalian cells might be compromised by...
10.
Scheidt T, Ruan H, Yu M, Lemke E
Mol Cell
. 2023 Jun;
83(12):1961-1963.
PMID: 37327772
Ataxin-2, an RNA-binding protein that is conserved across eukaryotes, is involved in stress granule assembly and age-associated neurodegenerative diseases. In this issue of Molecular Cell, Boeynaems et al. identify a...