Davide Comoletti
Overview
Explore the profile of Davide Comoletti including associated specialties, affiliations and a list of published articles.
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Articles
56
Citations
1996
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Recent Articles
1.
Diamanti T, Trobiani L, Mautone L, Serafini F, Gioia R, Ferrucci L, et al.
Traffic
. 2024 Jan;
25(1):e12930.
PMID: 38272450
Neuroligins are synaptic cell adhesion proteins with a role in synaptic function, implicated in neurodevelopmental disorders. The autism spectrum disorder-associated substitution Arg451Cys (R451C) in NLGN3 promotes a partial misfolding of...
2.
Libe-Philippot B, Lejeune A, Wierda K, Louros N, Erkol E, Vlaeminck I, et al.
Cell
. 2023 Dec;
186(26):5766-5783.e25.
PMID: 38134874
The enhanced cognitive abilities characterizing the human species result from specialized features of neurons and circuits. Here, we report that the hominid-specific gene LRRC37B encodes a receptor expressed in human...
3.
Pankhurst T, Buick K, Lange J, Marshall A, Button K, Palmer O, et al.
Cell Rep
. 2023 Mar;
42(4):112310.
PMID: 36989114
Protective immune responses against respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the mucosal immune system. However, most licensed vaccines are...
4.
Montgomerie I, Bird T, Palmer O, Mason N, Pankhurst T, Lawley B, et al.
iScience
. 2023 Feb;
26(4):106256.
PMID: 36845030
Emerging SARS-CoV-2 variants pose a threat to human health worldwide. SARS-CoV-2 receptor binding domain (RBD)-based vaccines are suitable candidates for booster vaccines, eliciting a focused antibody response enriched for virus...
5.
Wang L, Mirabella V, Dai R, Su X, Xu R, Jadali A, et al.
Mol Psychiatry
. 2022 Oct;
29(6):1620-1635.
PMID: 36280753
Mutations in many synaptic genes are associated with autism spectrum disorders (ASD), suggesting that synaptic dysfunction is a key driver of ASD pathogenesis. Among these mutations, the R451C substitution in...
6.
Akkermans O, Delloye-Bourgeois C, Peregrina C, Carrasquero-Ordaz M, Kokolaki M, Berbeira-Santana M, et al.
Cell
. 2022 Oct;
185(21):3931-3949.e26.
PMID: 36240740
Neural migration is a critical step during brain development that requires the interactions of cell-surface guidance receptors. Cancer cells often hijack these mechanisms to disseminate. Here, we reveal crystal structures...
7.
Turk L, Currie M, Dobson R, Comoletti D
Biophys J
. 2022 Jun;
121(13):2526-2537.
PMID: 35659645
Neuronal development and function are dependent in part on the several roles of the secreted glycoprotein Reelin. Endogenous proteases process this 400 kDa, modular protein, yielding N-terminal, central, and C-terminal...
8.
Martin-de-Saavedra M, Dos Santos M, Culotta L, Varea O, Spielman B, Parnell E, et al.
Neuron
. 2021 Dec;
110(4):627-643.e9.
PMID: 34921780
Although many neuronal membrane proteins undergo proteolytic cleavage, little is known about the biological significance of neuronal ectodomain shedding (ES). Here, we show that the neuronal sheddome is detectable in...
9.
Cui W, Gao N, Dong Z, Shen C, Zhang H, Luo B, et al.
Curr Biol
. 2021 Jun;
31(15):3330-3342.e7.
PMID: 34143959
Dopamine (DA) transmission is critical to motivation, movement, and emotion. Unlike glutamatergic and GABAergic synapses, the development of DA synapses is less understood. We show that bassoon (BSN) clusters along...
10.
Turk L, Kuang X, Pozzo V, Patel K, Chen M, Huynh K, et al.
Structure
. 2021 Jun;
29(10):1156-1170.e6.
PMID: 34089653
Reelin operates through canonical and non-canonical pathways that mediate several aspects of brain development and function. Reelin's dimeric central fragment (CF), generated through proteolytic cleavage, is required for the lipoprotein-receptor-dependent...