David W Staple
Overview
Explore the profile of David W Staple including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
391
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0
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Recent Articles
1.
Cornish P, Ermolenko D, Staple D, Hoang L, Hickerson R, Noller H, et al.
Proc Natl Acad Sci U S A
. 2009 Feb;
106(8):2571-6.
PMID: 19190181
The L1 stalk is a mobile domain of the large ribosomal subunit E site that interacts with the elbow of deacylated tRNA during protein synthesis. Here, by using single-molecule FRET,...
2.
Staple D, Venditti V, Niccolai N, Elson-Schwab L, Tor Y, Butcher S
Chembiochem
. 2007 Dec;
9(1):93-102.
PMID: 18058789
Aminoglycoside antibiotics are small-molecule drugs that bind RNA. The affinity and specificity of aminoglycoside binding to RNA can be increased through chemical modification, such as guanidinylation. Here, we report the...
3.
Marcheschi R, Staple D, Butcher S
J Mol Biol
. 2007 Sep;
373(3):652-63.
PMID: 17868691
Simian immunodeficiency virus (SIV), like its human homologues (HIV-1, HIV-2), requires a -1 translational frameshift event to properly synthesize all of the proteins required for viral replication. The frameshift mechanism...
4.
5.
Staple D, Butcher S
J Mol Biol
. 2005 Jun;
349(5):1011-23.
PMID: 15927637
Expression of the HIV reverse transcriptase and other essential viral enzymes requires a -1 translational frameshift. The frameshift event is induced by two highly conserved RNA elements within the HIV-1...
6.
Staple D, Butcher S
Nucleic Acids Res
. 2003 Jul;
31(15):4326-31.
PMID: 12888491
The translation of reverse transcriptase and other essential viral proteins from the HIV-1 Pol mRNA requires a programmed -1 ribosomal frameshift. This frameshift is induced by two highly conserved elements...