David Tung
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Explore the profile of David Tung including associated specialties, affiliations and a list of published articles.
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20
Citations
498
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Recent Articles
1.
Maitz C, Tate D, Bechtel S, Lunceford J, Henry C, Flesner B, et al.
Radiat Res
. 2021 Dec;
197(3):253-260.
PMID: 34855934
Hypoxia is associated with neoplastic tissue, protecting cancer cells from death by irradiation and chemotherapy. Identification of hypoxic volume of tumors could optimize patient selection for hypoxia-directed medical, immunological, and...
2.
Janku F, Zhang H, Pezeshki A, Goel S, Murthy R, Wang-Gillam A, et al.
Clin Cancer Res
. 2020 Oct;
27(1):96-106.
PMID: 33046513
Purpose: Intratumorally injected -NT (nontoxic; lacking the alpha toxin), an attenuated strain of , replicates within hypoxic tumor regions resulting in tumor-confined cell lysis and inflammatory response in animals, which...
3.
DeClue A, Axiak-Bechtel S, Zhang Y, Saha S, Zhang L, Tung D, et al.
Vet Res
. 2018 Apr;
49(1):38.
PMID: 29690928
Clostridium novyi-NT (CVN-NT) spores germinate in hypoxic regions of tumors and have successfully cured induced neoplasia in mouse models and resulted in objective tumor responses in naturally developing neoplasia in...
4.
Roberts N, Zhang L, Janku F, Collins A, Bai R, Staedtke V, et al.
Sci Transl Med
. 2014 Aug;
6(249):249ra111.
PMID: 25122639
Species of Clostridium bacteria are notable for their ability to lyse tumor cells growing in hypoxic environments. We show that an attenuated strain of Clostridium novyi (C. novyi-NT) induces a...
5.
Tung D, DeCrescenzo G, Welsch D, Cheung P, Bettegowda C, Saha S
World J Microbiol Biotechnol
. 2014 Aug;
30(11):3003-10.
PMID: 25085723
The nucleoside analogue, 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU) is a substrate for thymidine kinase (TK), which is commonly expressed in bacteria. It is currently being investigated in clinical studies as an in vivo...
6.
Little A, Tung D, Truong C, Lapinsky S, Burry L
CJEM
. 2014 May;
16(3):252-6.
PMID: 24852590
Colchicine has a low therapeutic index. Its toxic effects generally occur at doses ≥ 0.5 mg/kg. We present the case of a 39-year-old female with toxicity following ingestion of 0.28...
7.
Tung D, Cheung P, Wilson J, Tudor G, Booth C, Saha S
Curr Ther Res Clin Exp
. 2014 Mar;
73(4-5):150-64.
PMID: 24653517
Background: Radiation therapy is the most prescribed treatment for many oncologic indications. One of its common side effects is mucositis with hallmark apoptosis in the intestinal crypt and diarrhea. Objective:...
8.
Tung D, Cheung P, Tudor G, Booth C, Saha S
Curr Ther Res Clin Exp
. 2014 Mar;
72(6):262-72.
PMID: 24648594
Background: Fluorouracil (5-FU) is a pyrimidine analogue used as a cancer treatment. Its toxic side effects, including mucositis, are reported to occur in 40% of the treated patients. Because of...
9.
Tung D, Ciallella J, Hain H, Cheung P, Saha S
Curr Ther Res Clin Exp
. 2014 Jan;
75:71-6.
PMID: 24465047
Background: Trilostane was identified in an in vivo screen of compounds in a lipopolysaccharide model of inflammation to support a repurposing effort. There is no previous documentation of any anti-inflammatory...
10.
Tung D, Ciallella J, Cheung P, Saha S
Pharmacology
. 2012 Nov;
91(1-2):29-34.
PMID: 23146878
Background: Doxazosin is an α(1)-adrenergic receptor antagonist for the treatment of high blood pressure and benign prostatic hyperplasia. Peripheral α-adrenergic receptors have been implicated in inflammation. Aim: To examine the...