David Tamang
Overview
Explore the profile of David Tamang including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
489
Followers
0
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Recent Articles
1.
Hellmann M, Janne P, Opyrchal M, Hafez N, Raez L, Gabrilovich D, et al.
Clin Cancer Res
. 2020 Nov;
27(4):1019-1028.
PMID: 33203644
Purpose: New therapies are needed to treat immune checkpoint inhibitor-resistant non-small cell lung cancer (NSCLC) and identify biomarkers to personalize treatment. Epigenetic therapies, including histone deacetylase inhibitors, may synergize with...
2.
North B, Almeciga-Pinto I, Tamang D, Yang M, Jones S, Quayle S
PLoS One
. 2017 Mar;
12(3):e0173507.
PMID: 28264055
Thalidomide-based Immunomodulatory Drugs (IMiDs®), including lenalidomide and pomalidomide, are effective therapeutics for multiple myeloma. These agents have been approved with, or are under clinical development with, other targeted therapies including...
3.
Vogl D, Raje N, Jagannath S, Richardson P, Hari P, Orlowski R, et al.
Clin Cancer Res
. 2017 Jan;
23(13):3307-3315.
PMID: 28053023
Histone deacetylase (HDAC) inhibition improves the efficacy of proteasome inhibition for multiple myeloma but adds substantial toxicity. Preclinical models suggest that the observed synergy is due to the role of...
4.
Shearstone J, Golonzhka O, Chonkar A, Tamang D, van Duzer J, Jones S, et al.
PLoS One
. 2016 Apr;
11(4):e0153767.
PMID: 27073918
Therapeutic intervention aimed at reactivation of fetal hemoglobin protein (HbF) is a promising approach for ameliorating sickle cell disease (SCD) and β-thalassemia. Previous studies showed genetic knockdown of histone deacetylase...
5.
Santo L, Hideshima T, Kung A, Tseng J, Tamang D, Yang M, et al.
Blood
. 2012 Jan;
119(11):2579-89.
PMID: 22262760
Histone deacetylase (HDAC) enzymatic activity has been linked to the transcription of DNA in cancers including multiple myeloma (MM). Therefore, HDAC inhibitors used alone and in combination are being actively...