David T Long
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Explore the profile of David T Long including associated specialties, affiliations and a list of published articles.
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47
Citations
1225
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Recent Articles
1.
Ampolini E, Jimenez-Sainz J, Long D
Target Oncol
. 2025 Mar;
PMID: 40024979
The ataxia-telangiectasia mutated (ATM) protein kinase plays a critical role in activating the cellular response to DNA double-strand breaks and promoting homology-directed repair. ATM is frequently mutated in cancer, contributing...
2.
Zuccotti A, Al-Fatyan F, Ferretti G, Bertolini I, Long D, Sahin O, et al.
J Cell Physiol
. 2025 Feb;
240(2):e70006.
PMID: 39943735
Human skin is the largest organ of the human body and accounts for approximately fifteen percent of the total bodyweight. Its main physiological role is to protect the body against...
3.
Vaena S, Romeo M, Mina-Abouda M, Funk E, Fullbright G, Long D, et al.
Cell Cycle
. 2024 Sep;
:1-21.
PMID: 39299930
Hydroxychloroquine (HCQ) and chloroquine are repurposed drugs known to disrupt autophagy, a molecular recycling pathway essential for tumor cell survival, chemotherapeutic resistance, and stemness. We pursued a multi-omic strategy in...
4.
Blackman A, Rees A, Bowers R, Jones C, Vaena S, Clark M, et al.
Cancer Res Commun
. 2024 Sep;
4(9):2525-2538.
PMID: 39225558
Significance: Mouse models using transgenes which generate spontaneous cancers are essential tools to examine the etiology of human diseases. Here, the first Myc-driven spontaneous model is described as a valid...
5.
Uboveja A, Huang Z, Buj R, Amalric A, Wang H, Tangudu N, et al.
bioRxiv
. 2024 Feb;
PMID: 38370789
Homologous recombination (HR) deficiency enhances sensitivity to DNA damaging agents commonly used to treat cancer. In HR-proficient cancers, metabolic mechanisms driving response or resistance to DNA damaging agents remain unclear....
6.
Blackman A, Rees A, Bowers R, Jones C, Vaena S, Clark M, et al.
bioRxiv
. 2024 Feb;
PMID: 38352443
Genetically engineered mouse models (GEMM) have fundamentally changed how ovarian cancer etiology, early detection, and treatment is understood. However, previous GEMMs of high-grade serous ovarian cancer (HGSOC) have had to...
7.
Liu L, Lin B, Yin S, Ball L, Delaney J, Long D, et al.
Sci Adv
. 2022 Dec;
8(49):eadd8928.
PMID: 36475791
BRD4 functions as an epigenetic reader and plays a crucial role in regulating transcription and genome stability. Dysregulation of BRD4 is frequently observed in various human cancers. However, the molecular...
8.
Quaas C, Lin B, Long D
J Biol Chem
. 2022 Oct;
298(11):102578.
PMID: 36220390
Modification of histones provides a dynamic mechanism to regulate chromatin structure and access to DNA. Histone acetylation, in particular, plays a prominent role in controlling the interaction between DNA, histones,...
9.
Barrows J, Lin B, Quaas C, Fullbright G, Wallace E, Long D
Nat Commun
. 2022 May;
13(1):3016.
PMID: 35641523
Double-strand breaks (DSBs) are one of the most toxic forms of DNA damage and represent a major source of genomic instability. Members of the bromodomain and extra-terminal (BET) protein family...
10.
Bowers R, Jones C, Paz E, Barrows J, Armeson K, Long D, et al.
Nucleic Acids Res
. 2022 Apr;
50(7):3673-3692.
PMID: 35380699
Haploinsufficiency drives Darwinian evolution. Siblings, while alike in many aspects, differ due to monoallelic differences inherited from each parent. In cancer, solid tumors exhibit aneuploid genetics resulting in hundreds to...