David T Humphreys
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Explore the profile of David T Humphreys including associated specialties, affiliations and a list of published articles.
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46
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3036
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Recent Articles
1.
Impaired yolk sac NAD metabolism disrupts murine embryogenesis with relevance to human birth defects
Bozon K, Cuny H, Sheng D, Martin E, Sipka A, Young P, et al.
Elife
. 2025 Mar;
13.
PMID: 40047807
Congenital malformations can originate from numerous genetic or non-genetic factors but in most cases the causes are unknown. Genetic disruption of nicotinamide adenine dinucleotide (NAD) de novo synthesis causes multiple...
2.
Zhuang X, Wang Q, Joost S, Ferrena A, Humphreys D, Li Z, et al.
Nature
. 2024 Dec;
637(8044):184-194.
PMID: 39633048
Ageing is associated with a decline in the number and fitness of adult stem cells. Ageing-associated loss of stemness is posited to suppress tumorigenesis, but this hypothesis has not been...
3.
Zhuang X, Wang Q, Joost S, Ferrena A, Humphreys D, Li Z, et al.
bioRxiv
. 2024 Jul;
PMID: 38979280
Aging is associated with a decline in the number and fitness of adult stem cells . Aging-associated loss of stemness is posited to suppress tumorigenesis , but this hypothesis has...
4.
Patrick R, Janbandhu V, Tallapragada V, Tan S, McKinna E, Contreras O, et al.
Sci Adv
. 2024 Jun;
10(25):eadk8501.
PMID: 38905342
Single-cell technology has allowed researchers to probe tissue complexity and dynamics at unprecedented depth in health and disease. However, the generation of high-dimensionality single-cell atlases and virtual three-dimensional tissues requires...
5.
Humphreys D, Lewis A, Pan-Castillo B, Berti G, Mein C, Wozniak E, et al.
J Cell Mol Med
. 2024 Apr;
28(9):e18344.
PMID: 38685679
Single cell RNA sequencing of human full thickness Crohn's disease (CD) small bowel resection specimens was used to identify potential therapeutic targets for stricturing (S) CD. Using an unbiased approach,...
6.
Lewis A, Humphreys D, Pan-Castillo B, Berti G, Felice C, Gordon H, et al.
J Crohns Colitis
. 2023 Dec;
18(6):895-907.
PMID: 38069679
Background And Aims: No effective therapeutic intervention exists for intestinal fibrosis in Crohn's disease [CD]. We characterized fibroblast subtypes, epigenetic and metabolic changes, and signalling pathways in CD fibrosis to...
7.
Murtha L, Hardy S, Mabotuwana N, Bigland M, Bailey T, Raguram K, et al.
Sci Rep
. 2023 Sep;
13(1):14995.
PMID: 37696945
Despite the high prevalence of heart failure in the western world, there are few effective treatments. Fibulin-3 is a protein involved in extracellular matrix (ECM) structural integrity, however its role...
8.
Mullari M, Fossat N, Skotte N, Asenjo-Martinez A, Humphreys D, Bukh J, et al.
Nat Commun
. 2023 Jul;
14(1):4348.
PMID: 37468457
RNA-binding proteins (RBPs) are key players regulating RNA processing and are associated with disorders ranging from cancer to neurodegeneration. Here, we present a proteomics workflow for large-scale identification of RBPs...
9.
Moradi Marjaneh M, Kirk E, Patrick R, Alankarage D, Humphreys D, Del Monte-Nieto G, et al.
Elife
. 2023 Jun;
12.
PMID: 37272612
Unlike single-gene mutations leading to Mendelian conditions, common human diseases are likely to be emergent phenomena arising from multilayer, multiscale, and highly interconnected interactions. Atrial and ventricular septal defects are...
10.
Ridone P, Ishida T, Lin A, Humphreys D, Giannoulatou E, Sowa Y, et al.
Sci Adv
. 2022 Nov;
8(47):eabq2492.
PMID: 36417540
Determining which cellular processes facilitate adaptation requires a tractable experimental model where an environmental cue can generate variants that rescue function. The bacterial flagellar motor (BFM) is an excellent candidate-an...