David Shugar
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Explore the profile of David Shugar including associated specialties, affiliations and a list of published articles.
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42
Citations
456
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Recent Articles
1.
Antosiewicz J, Shugar D
Biophys Rev
. 2017 May;
8(2):151-161.
PMID: 28510058
Spectroscopic properties of tyrosine residues may be employed in structural studies of proteins. Here we discuss several different types of UV-Vis spectroscopy, like normal, difference and second-derivative UV absorption spectroscopy,...
2.
Antosiewicz J, Shugar D
Biophys Rev
. 2017 May;
8(2):163-177.
PMID: 28510057
In Part 2 we discuss application of several different types of UV-Vis spectroscopy, such as normal, difference, and second-derivative UV absorption spectroscopy, fluorescence spectroscopy, linear and circular dichroism spectroscopy, and...
3.
Poznanski J, Winiewska M, Czapinska H, Poznanska A, Shugar D
Acta Biochim Pol
. 2016 Apr;
63(2):203-14.
PMID: 27104680
Analysis of 664 known structures of protein kinase complexes with halogenated ligands revealed 424 short contacts between a halogen atom and a potential protein X-bond acceptor, the topology and geometry...
4.
Fraczyk T, Ruman T, Wilk P, Palmowski P, Rogowska-Wrzesinska A, Ciesla J, et al.
Biochim Biophys Acta
. 2015 Aug;
1854(12):1922-1934.
PMID: 26315778
Thymidylate synthase (TS) may undergo phosphorylation endogenously in mammalian cells, and as a recombinant protein expressed in bacterial cells, as indicated by the reaction of purified enzyme protein with Pro-Q®...
5.
Shugar D, Fabbro D, Poznanski J
Biochim Biophys Acta
. 2015 Jul;
1854(10 Pt B):1553-4.
PMID: 26160750
No abstract available.
6.
Winiewska M, Kucinska K, Makowska M, Poznanski J, Shugar D
Biochim Biophys Acta
. 2015 Apr;
1854(10 Pt B):1708-17.
PMID: 25891901
The interaction of human CK2α (hCK2α) with nine halogenated benzotriazoles, TBBt and its analogues representing all possible patterns of halogenation on the benzene ring of benzotriazole, was studied by biophysical...
7.
Winiewska M, Makowska M, Maj P, Wielechowska M, Bretner M, Poznanski J, et al.
Biochem Biophys Res Commun
. 2014 Dec;
456(1):282-7.
PMID: 25450618
The interaction of human CK2α with a series of tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) analogs, in which one of the bromine atoms proximal to the triazole/imidazole ring is replaced by...
8.
Wierzchowski J, Antosiewicz J, Shugar D
Mol Biosyst
. 2014 Aug;
10(11):2756-74.
PMID: 25124808
The 8-azapurines, and their 7-deaza and 9-deaza congeners, represent a unique class of isosteric (isomorphic) analogues of the natural purines, frequently capable of substituting for the latter in many biochemical...
9.
Poznanski J, Poznanska A, Shugar D
PLoS One
. 2014 Jun;
9(6):e99984.
PMID: 24933273
Halogen bonding in ligand-protein complexes is currently widely exploited, e.g. in drug design or supramolecular chemistry. But little attention has been directed to other effects that may result from replacement...
10.
Singh R, Miazga A, Dabrowska A, Lipniacki A, Piasek A, Kulikowski T, et al.
Antivir Chem Chemother
. 2013 Aug;
23(6):231-5.
PMID: 23985753
Background: To improve in vitro antiviral activity and selectivity of stavudine (d4T), a range of its bi-functional prodrugs, 5'-O-myristoylated derivatives, have been synthesized. Methods: Stavudine 5'-O-myristoylated esters were synthesized using...