David Scadden
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Explore the profile of David Scadden including associated specialties, affiliations and a list of published articles.
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17
Citations
381
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Recent Articles
1.
Bonilla G, Morris A, Kundu S, DuCasse A, Kirkpatrick G, Jeffries N, et al.
bioRxiv
. 2024 Mar;
PMID: 38496490
Molecular mechanisms driving clonal aggressiveness in leukemia are not fully understood. We tracked and analyzed MLL-rearranged leukemic clones independently evolving towards higher aggressiveness. More aggressive subclones lost their growth differential...
2.
Zhang S, Paccalet A, Rohde D, Cremer S, Hulsmans M, Lee I, et al.
Nat Cardiovasc Res
. 2024 Feb;
2(12):1277-1290.
PMID: 38344689
After myocardial infarction (MI), emergency hematopoiesis produces inflammatory myeloid cells that accelerate atherosclerosis and promote heart failure. Since the balance between glycolysis and mitochondrial metabolism regulates hematopoietic stem cell homeostasis,...
3.
Fast E, Sporrij A, Manning M, Rocha E, Yang S, Zhou Y, et al.
Elife
. 2021 Dec;
10.
PMID: 34939923
Hematopoietic stem cells (HSCs) must ensure adequate blood cell production following distinct external stressors. A comprehensive understanding of in vivo heterogeneity and specificity of HSC responses to external stimuli is...
4.
Fang S, Chen S, Nurmi H, Leppanen V, Jeltsch M, Scadden D, et al.
Blood
. 2020 Aug;
136(16):1871-1883.
PMID: 32842144
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) stem cell niche, which provides a vital source of HSC regulatory signals. Radiation and chemotherapy disrupt the HSC niche, including...
5.
Shao L, Chang J, Feng W, Wang X, Williamson E, Li Y, et al.
Nat Commun
. 2018 Jun;
9(1):2377.
PMID: 29915352
The transition of hematopoiesis from the fetal liver (FL) to the bone marrow (BM) is incompletely characterized. We demonstrate that the Wiskott-Aldrich syndrome verprolin-homologous protein (WAVE) complex 2 is required...
6.
Simic P, Zainabadi K, Bell E, Sykes D, Saez B, Lotinun S, et al.
EMBO Mol Med
. 2013 Feb;
5(3):430-40.
PMID: 23364955
Mesenchymal stem cells (MSCs) are multi-potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging. We investigated whether the sirtuin SIRT1 had a function...
7.
Pozzi S, Fulciniti M, Yan H, Vallet S, Eda H, Patel K, et al.
Bone
. 2013 Jan;
53(2):487-96.
PMID: 23333523
Over-expression of the protein Dickkopf-1 (Dkk1) has been associated with multiple myeloma bone disease. Previous reports with the use of anti-Dkk1 neutralizing Ab directed strategies have demonstrated a pro-anabolic effect...
8.
Scadden D, Srivastava A
Cell Stem Cell
. 2012 Feb;
10(2):149-50.
PMID: 22305564
Here, the International Society for Stem Cell Research (ISSCR) Clinical Translation Committee introduces a series of disease-specific articles, outlining the challenges surrounding the clinical translation of stem cell therapeutics.
9.
Ferraro F, Lo Celso C, Scadden D
Adv Exp Med Biol
. 2011 Jan;
695:155-68.
PMID: 21222205
Stem cells participate in dynamic physiologic systems that dictate the outcome of developmental events and organismal stress, Since these cells are fundamental to tissue maintenance and repair, the signals they...
10.
Adams G, Scadden D
Discov Med
. 2010 Aug;
4(21):118-9.
PMID: 20705006
Extract: Stem cells modulate tissue formation and repair based on a complex interaction of cell autonomous and non-autonomous regulatory mechanisms. While reductionist approaches to understanding stem cell control continue to...