Jonas Larsson
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Explore the profile of Jonas Larsson including associated specialties, affiliations and a list of published articles.
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95
Citations
2687
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Recent Articles
1.
Hughes D, Mousa A, Musumeci C, Larsson M, Shameem M, Aydemir U, et al.
Nano Lett
. 2025 Feb;
25(8):3059-3065.
PMID: 39943879
Free-standing nanowires can gain intracellular access without causing stress or apoptosis. Current approaches to generate nanowires focus on lithographic patterning and inorganic materials (Si, GaAs, AlO, etc.) while organic materials...
2.
Truong P, Shen S, Joshi S, Islam M, Zhong L, Raftery M, et al.
Nat Commun
. 2024 Aug;
15(1):7360.
PMID: 39198401
Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide...
3.
Rydstrom A, Grahn T, Niroula A, Mansell E, van der Garde M, Pertesi M, et al.
Exp Hematol
. 2023 Sep;
127:40-51.
PMID: 37666355
Hematopoietic stem cells (HSCs) enable hematopoietic stem cell transplantation (HCT) through their ability to replenish the entire blood system. Proliferation of HSCs is linked to decreased reconstitution potential, and a...
4.
Silverio-Alves R, Kurochkin I, Rydstrom A, Vazquez Echegaray C, Haider J, Nicholls M, et al.
Nat Commun
. 2023 Aug;
14(1):4645.
PMID: 37580379
In mitosis, most transcription factors detach from chromatin, but some are retained and bookmark genomic sites. Mitotic bookmarking has been implicated in lineage inheritance, pluripotency and reprogramming. However, the biological...
5.
Safaee Talkhoncheh M, Baudet A, Ek F, Subramaniam A, Kao Y, Miharada N, et al.
Blood Adv
. 2023 Jul;
7(24):7407-7417.
PMID: 37487020
Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. To elucidate regulatory mechanisms governing the maintenance and propagation of human HSCs...
6.
Liu Y, Schmiderer L, Hjort M, Lang S, Bremborg T, Rydstrom A, et al.
Haematologica
. 2023 May;
108(11):3095-3109.
PMID: 37199130
Diamond-Blackfan anemia is a rare genetic bone marrow failure disorder which is usually caused by mutations in ribosomal protein genes. In the present study, we generated a traceable RPS19-deficient cell...
7.
Rydstrom A, Mansell E, Sigurdsson V, Sjoberg J, Soneji S, Miharada K, et al.
Stem Cell Reports
. 2023 Mar;
18(3):736-748.
PMID: 36868231
Mouse hematopoietic stem cells (HSCs) have been extensively defined both molecularly and functionally at steady state, while regenerative stress induces immunophenotypical changes that limit high purity isolation and analysis. It...
8.
Schmiderer L, Yudovich D, Oburoglu L, Hjort M, Larsson J
Sci Rep
. 2022 Nov;
12(1):18687.
PMID: 36333335
Achieving CRISPR Cas9-based manipulation of mitochondrial DNA (mtDNA) has been a long-standing goal and would be of great relevance for disease modeling and for clinical applications. In this project, we...
9.
Backstrom A, Yudovich D, Zemaitis K, Nilsen Falck L, Subramaniam A, Larsson J
Sci Rep
. 2022 Oct;
12(1):18169.
PMID: 36307542
The CRISPR/Cas9 system offers enormous versatility for functional genomics but many applications have proven to be challenging in primary human cells compared to cell lines or mouse cells. Here, to...
10.
Zemaitis K, Subramaniam A, Galeev R, Prosz A, Jassinskaja M, Hansson J, et al.
Exp Hematol
. 2022 Aug;
115:20-29.
PMID: 36041657
The molecular mechanisms regulating key fate decisions of hematopoietic stem cells (HSCs) remain incompletely understood. Here, we targeted global shRNA libraries to primary human hematopoietic stem and progenitor cells (HSPCs)...