David Savitsky
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Explore the profile of David Savitsky including associated specialties, affiliations and a list of published articles.
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11
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1451
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Recent Articles
1.
Gombos R, Gonzalez A, Manrique M, Chand D, Savitsky D, Morin B, et al.
PLoS One
. 2018 Apr;
13(4):e0191926.
PMID: 29617360
CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with antigen-presenting cells. Anti-CTLA-4 antibodies enhance tumor-specific immunity through a variety...
2.
Savitsky D, Tamura T, Yanai H, Taniguchi T
Cancer Immunol Immunother
. 2010 Jan;
59(4):489-510.
PMID: 20049431
Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies...
3.
Yanai H, Ban T, Wang Z, Choi M, Kawamura T, Negishi H, et al.
Nature
. 2009 Nov;
462(7269):99-103.
PMID: 19890330
The activation of innate immune responses by nucleic acids is crucial to protective and pathological immunities and is mediated by the transmembrane Toll-like receptors (TLRs) and cytosolic receptors. However, it...
4.
Choi M, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R, et al.
Proc Natl Acad Sci U S A
. 2009 Oct;
106(42):17870-5.
PMID: 19805092
The activation of the innate immune responses by DNA exposed within the cytosol has gained much attention and, in this context, several cytosolic DNA sensors have been identified. However, previous...
5.
Yanai H, Savitsky D, Tamura T, Taniguchi T
Curr Opin Immunol
. 2009 Apr;
21(1):17-22.
PMID: 19362700
The sensing of nucleic acids by pattern recognition receptors is a central feature of innate immunity and is mediated by two types of receptors, Toll-like receptors and cytosolic receptors. Indeed,...
6.
Lord C, Savitsky D, Sitcheran R, Calame K, Wright J, Ting J, et al.
J Immunol
. 2009 Feb;
182(5):2948-58.
PMID: 19234190
NLR (nucleotide-binding domain, leucine-rich repeat) proteins are intracellular regulators of host defense and immunity. One NLR gene, NLRP12 (NLR family, pyrin domain containing 12)/Monarch-1, has emerged as an important inhibitor...
7.
Tamura T, Yanai H, Savitsky D, Taniguchi T
Annu Rev Immunol
. 2008 Feb;
26:535-84.
PMID: 18303999
The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was identified in the late 1980s in the context of research into the type I interferon system. Subsequent...
8.
Magnusdottir E, Kalachikov S, Mizukoshi K, Savitsky D, Ishida-Yamamoto A, Panteleyev A, et al.
Proc Natl Acad Sci U S A
. 2007 Sep;
104(38):14988-93.
PMID: 17846422
The cornified layer is a compacted lattice of lipid-embedded corneocytes that provides an organism's barrier to the external environment. Cornification is the final differentiative step for epidermal keratinocytes and involves...
9.
Savitsky D, Cimmino L, Kuo T, Martins G, Calame K
Adv Exp Med Biol
. 2007 Mar;
596:9-30.
PMID: 17338172
No abstract available.
10.
Savitsky D, Calame K
J Exp Med
. 2006 Sep;
203(10):2305-14.
PMID: 16954370
B-1 B cells produce circulating natural antibodies that provide "innate-like" protection against bacterial and viral pathogens. They also provide adaptive responses to blood and air-borne pathogens. B lymphocyte-induced maturation protein...