David S Siscovick
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Explore the profile of David S Siscovick including associated specialties, affiliations and a list of published articles.
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498
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33194
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Recent Articles
31.
Fretts A, Hazen S, Jensen P, Budoff M, Sitlani C, Wang M, et al.
JAMA Netw Open
. 2022 May;
5(5):e2213242.
PMID: 35594043
Importance: Little is known about the association of trimethylamine N-oxide (TMAO), a novel plasma metabolite derived from L-carnitine and phosphatidylcholine, and related metabolites (ie, choline, betaine, carnitine, and butyrobetaine) with...
32.
Shitole S, Biggs M, Ix J, Fretts A, Tracy R, Siscovick D, et al.
Am J Epidemiol
. 2022 Mar;
191(7):1235-1247.
PMID: 35247051
To evaluate the association of nonesterified fatty acids (NEFA) with dysglycemia in older adults, NEFA levels were measured among participants in the Cardiovascular Health Study (United States; enrolled 1989-1993). Associations...
33.
Lai H, Imamura F, Ardisson Korat A, Murphy R, Tintle N, Bassett J, et al.
Diabetes Care
. 2022 Feb;
45(4):854-863.
PMID: 35142845
Objective: Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations...
34.
Huang N, Biggs M, Matthan N, Djousse L, Longstreth Jr W, Mukamal K, et al.
J Am Heart Assoc
. 2021 Nov;
10(22):e022725.
PMID: 34755529
Background Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies. We evaluated the associations between incident stroke and serum...
35.
Fretts A, Jensen P, Hoofnagle A, McKnight B, Sitlani C, Siscovick D, et al.
Clin Chem
. 2021 Sep;
67(12):1650-1659.
PMID: 34580702
Background: Recent studies suggest that associations of ceramides (Cer) and sphingomyelins (SM) with health outcomes differ according to the fatty acid acylated to the sphingoid backbone. The purpose of this...
36.
Fretts A, Jensen P, Hoofnagle A, McKnight B, Howard B, Umans J, et al.
J Lipid Res
. 2021 Sep;
62:100119.
PMID: 34555371
Recent studies suggest that the type of saturated fatty acid bound to sphingolipids influences the biological activity of those sphingolipids. However, it is unknown whether associations of sphingolipids with diabetes...
37.
Limpitikul W, Dewland T, Vittinghoff E, Soliman E, Nah G, Fang C, et al.
Heart
. 2021 Sep;
108(2):105-110.
PMID: 34493549
Objective: A higher premature ventricular complex (PVC) frequency is associated with incident congestive heart failure (CHF) and death. While certain PVC characteristics may contribute to that risk, the current literature...
38.
Lemaitre R, Jensen P, Wang Z, Fretts A, McKnight B, Nemet I, et al.
JAMA Netw Open
. 2021 Aug;
4(8):e2122844.
PMID: 34448864
Importance: Although rodent studies suggest that trimethylamine N-oxide (TMAO) influences glucose homeostasis and risk of type 2 diabetes, evidence in humans is limited. Objective: To examine the associations of serial...
39.
Lee Y, Nemet I, Wang Z, Lai H, de Oliveira Otto M, Lemaitre R, et al.
J Am Heart Assoc
. 2021 Aug;
10(17):e020646.
PMID: 34398665
Background Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of dietary choline, L-carnitine, and phosphatidylcholine-rich foods. On the basis of experimental studies and patients with prevalent disease, elevated plasma TMAO...
40.
Bockus L, Biggs M, Lai H, de Olivera Otto M, Fretts A, McKnight B, et al.
JAMA Netw Open
. 2021 Aug;
4(8):e2120616.
PMID: 34383061
Importance: Identifying novel factors that protect against age-related diseases and promote healthy aging is critical to public health. Higher levels of circulating very-long-chain saturated fatty acids (VLSFAs) are integrated biomarkers...