David S Pearson
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Explore the profile of David S Pearson including associated specialties, affiliations and a list of published articles.
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10
Citations
383
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Recent Articles
1.
Dos Santos A, Fili N, Pearson D, Hari-Gupta Y, Toseland C
Biophys J
. 2021 Jan;
120(4):631-641.
PMID: 33453266
Mechanobiology is focused on how the physical forces and mechanical properties of proteins, cells, and tissues contribute to physiology and disease. Although the response of proteins and cells to mechanical...
2.
Jenkins D, Pearson D, Harvey A, Sylvester I, Geeves M, Pinheiro T
Eur Biophys J
. 2009 Mar;
38(5):625-635.
PMID: 19255752
The conversion of the cellular form of the prion protein (PrP(C)) to an altered disease state, generally denoted as scrapie isoform (PrP(Sc)), appears to be a crucial molecular event in...
3.
Pearson D, Swartz D, Geeves M
Biochemistry
. 2008 Oct;
47(46):12146-58.
PMID: 18942859
We have used rapid pressure jump and stopped-flow fluorometry to investigate calcium and magnesium binding to F29W chicken skeletal troponin C. Increased pressure perturbed calcium binding to the N-terminal sites...
4.
Malnasi-Csizmadia A, Toth J, Pearson D, Hetenyi C, Nyitray L, Geeves M, et al.
J Biol Chem
. 2007 Apr;
282(24):17658-64.
PMID: 17449872
After ATP binding the myosin head undergoes a large structural rearrangement called the recovery stroke. This transition brings catalytic residues into place to enable ATP hydrolysis, and at the same...
5.
Kintses B, Gyimesi M, Pearson D, Geeves M, Zeng W, Bagshaw C, et al.
EMBO J
. 2007 Jan;
26(1):265-74.
PMID: 17213877
The conserved switch 1 loop of P-loop NTPases is implicated as a central element that transmits information between the nucleotide-binding pocket and the binding site of the partner proteins. Recent...
6.
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1
Mogensen E, Janbon G, Chaloupka J, Steegborn C, Shun Fu M, Moyrand F, et al.
Eukaryot Cell
. 2006 Jan;
5(1):103-11.
PMID: 16400172
Cryptococcus neoformans, a fungal pathogen of humans, causes fatal meningitis in immunocompromised patients. Its virulence is mainly determined by the elaboration of a polysaccharide capsule surrounding its cell wall. During...
7.
McAnaney T, Zeng W, Doe C, Bhanji N, Wakelin S, Pearson D, et al.
Biochemistry
. 2005 Apr;
44(14):5510-24.
PMID: 15807545
Yellow fluorescent protein (YFP 10C) is widely used as a probe in biology, but its complex photochemistry gives rise to unusual behavior that requires fuller definition. Here we characterize the...
8.
PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data
Bahl A, Brunk B, Crabtree J, Fraunholz M, Gajria B, Grant G, et al.
Nucleic Acids Res
. 2003 Jan;
31(1):212-5.
PMID: 12519984
PlasmoDB (http://PlasmoDB.org) is the official database of the Plasmodium falciparum genome sequencing consortium. This resource incorporates the recently completed P. falciparum genome sequence and annotation, as well as draft sequence...
9.
Kissinger J, Brunk B, Crabtree J, Fraunholz M, Gajria B, Milgram A, et al.
Nature
. 2002 Oct;
419(6906):490-2.
PMID: 12368860
No abstract available.
10.
Pearson D, Holtermann G, Ellison P, Cremo C, Geeves M
Biochem J
. 2002 May;
366(Pt 2):643-51.
PMID: 12010120
Reactions involving proteins frequently involve large changes in volume, which allows the equilibrium position to be perturbed by changes in pressure. Rapid changes in pressure can thus be used to...