David S Peal
Overview
Explore the profile of David S Peal including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
378
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0
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Recent Articles
1.
Farrar E, Hiriart E, Mahmut A, Jagla B, Peal D, Milan D, et al.
Sci Adv
. 2021 Nov;
7(45):eabf7910.
PMID: 34739324
Cell plasticity plays a key role in embryos by maintaining the differentiation potential of progenitors. Whether postnatal somatic cells revert to an embryonic-like naïve state regaining plasticity and redifferentiate into...
2.
Durst R, Sauls K, Peal D, deVlaming A, Toomer K, Leyne M, et al.
Nature
. 2015 Aug;
525(7567):109-13.
PMID: 26258302
Mitral valve prolapse (MVP) is a common cardiac valve disease that affects nearly 1 in 40 individuals. It can manifest as mitral regurgitation and is the leading indication for mitral...
3.
den Hoed M, Eijgelsheim M, Esko T, Brundel B, Peal D, Evans D, et al.
Nat Genet
. 2013 Apr;
45(6):621-31.
PMID: 23583979
Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14...
4.
Kolpa H, Peal D, Lynch S, Giokas A, Ghatak S, Misra S, et al.
Development
. 2013 Apr;
140(10):2172-80.
PMID: 23578931
The discovery of small non-coding microRNAs has revealed novel mechanisms of post-translational regulation of gene expression, the implications of which are still incompletely understood. We focused on microRNA 21 (miR-21),...
5.
Peal D, Lynch S, Milan D
J Cardiovasc Transl Res
. 2011 Sep;
4(6):720-6.
PMID: 21948390
Proper atrioventricular canal (AVC) patterning and subsequent valvulogenesis is a complex process, and defects can result in disease or early death. The zebrafish Danio rerio has become a useful model...
6.
Peal D, Mills R, Lynch S, Mosley J, Lim E, Ellinor P, et al.
Circulation
. 2010 Nov;
123(1):23-30.
PMID: 21098441
Background: Genetic long QT (LQT) syndrome is a life-threatening disorder caused by mutations that result in prolongation of cardiac repolarization. Recent work has demonstrated that a zebrafish model of LQT...
7.
Peal D, Peterson R, Milan D
J Cardiovasc Transl Res
. 2010 Aug;
3(5):454-60.
PMID: 20680709
Small molecule screens have become useful tools in ongoing efforts to understand complex biologic systems and disease states. These screens can identify compounds that specifically affect signaling pathways, development, and...
8.
Peal D, Burns C, MacRae C, Milan D
Dev Dyn
. 2009 Nov;
238(12):3103-10.
PMID: 19890913
Defects in cardiac valvulogenesis are a common cause of congenital heart disease, and the study of this process promises to provide mechanistic insights and lead to novel therapeutics. Normal valve...