David J Milan
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Explore the profile of David J Milan including associated specialties, affiliations and a list of published articles.
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67
Citations
3753
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Recent Articles
1.
Jameson H, Hanley A, Hill M, Xiao L, Ye J, Bapat A, et al.
Circ Res
. 2023 Jul;
133(4):313-329.
PMID: 37449401
Background: (zinc finger homeobox 3), a gene that encodes a large transcription factor, is at the second-most significantly associated locus with atrial fibrillation (AF), but its function in the heart...
2.
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, et al.
Science
. 2023 Jul;
381(6654):231-239.
PMID: 37440641
Atrial fibrillation disrupts contraction of the atria, leading to stroke and heart failure. We deciphered how immune and stromal cells contribute to atrial fibrillation. Single-cell transcriptomes from human atria documented...
3.
Bapat A, Schloss M, Yamazoe M, Grune J, Hulsmans M, Milan D, et al.
Circulation
. 2023 Mar;
147(13):1047-1049.
PMID: 36972346
No abstract available.
4.
Grune J, Lewis A, Yamazoe M, Hulsmans M, Rohde D, Xiao L, et al.
Nat Cardiovasc Res
. 2022 Aug;
1(7):649-664.
PMID: 36034743
Sudden cardiac death, arising from abnormal electrical conduction, occurs frequently in patients with coronary heart disease. Myocardial ischemia simultaneously induces arrhythmia and massive myocardial leukocyte changes. In this study, we...
5.
Roselli C, Yu M, Nauffal V, Georges A, Yang Q, Love K, et al.
Eur Heart J
. 2022 Mar;
43(17):1668-1680.
PMID: 35245370
Aims: Mitral valve prolapse (MVP) is a common valvular heart disease with a prevalence of >2% in the general adult population. Despite this high incidence, there is a limited understanding...
6.
Farrar E, Hiriart E, Mahmut A, Jagla B, Peal D, Milan D, et al.
Sci Adv
. 2021 Nov;
7(45):eabf7910.
PMID: 34739324
Cell plasticity plays a key role in embryos by maintaining the differentiation potential of progenitors. Whether postnatal somatic cells revert to an embryonic-like naïve state regaining plasticity and redifferentiate into...
7.
Tan J, Guyette J, Miki K, Xiao L, Kaur G, Wu T, et al.
Nat Commun
. 2021 Aug;
12(1):4997.
PMID: 34404774
Epicardial formation is necessary for normal myocardial morphogenesis. Here, we show that differentiating hiPSC-derived lateral plate mesoderm with BMP4, RA and VEGF (BVR) can generate a premature form of epicardial...
8.
Liu X, Wang S, Guo X, Li Y, Ogurlu R, Lu F, et al.
Circulation
. 2021 Apr;
143(19):1894-1911.
PMID: 33793303
Background: Mutations in tafazzin (), a gene required for biogenesis of cardiolipin, the signature phospholipid of the inner mitochondrial membrane, causes Barth syndrome (BTHS). Cardiomyopathy and risk of sudden cardiac...
9.
Xiao L, Salem J, Clauss S, Hanley A, Bapat A, Hulsmans M, et al.
Circulation
. 2020 Oct;
142(25):2443-2455.
PMID: 33092403
Background: Ibrutinib is a Bruton tyrosine kinase inhibitor with remarkable efficacy against B-cell cancers. Ibrutinib also increases the risk of atrial fibrillation (AF), which remains poorly understood. Methods: We performed...
10.
Toomer K, Yu M, Fulmer D, Guo L, Moore K, Moore R, et al.
Sci Transl Med
. 2019 May;
11(493).
PMID: 31118289
Mitral valve prolapse (MVP) affects 1 in 40 people and is the most common indication for mitral valve surgery. MVP can cause arrhythmias, heart failure, and sudden cardiac death, and...